Protection of Human Subjects | SPA | University of Nebraska Medical Center

UNMC’s Institutional Review Board (IRB) assure the protection of all human subjects in research projects conducted by anyone on the premises of the University of Nebraska Medical Center/The Nebraska Medical Center/UNO and conducted elsewhere by faculty, students, staff, or other representatives of the University of Nebraska Medical Center in connection with their institutional responsibilities.

During proposal review, a sponsor will ask for documentation of IRB approval. Also, before award set-up and during the project period, SPAdmin links projects to IRB protocol and monitors the status. A PI cannot conduct human subjects research without an active IRB protocol (or determination by the IRB that the project is exempt from HHS regulations).

45 CFR 46 Compliance

In accordance with Health and Human Services Regulations for Protection of Human Subjects (45 CFR 46), an institutional review board committee, composed of members from a variety of scientific disciplines as well as community members, assists investigators in the protection of the rights and welfare of human subjects. All human research projects must be reviewed and approved by the IRB prior to initiation and then conducted in full compliance with the IRB guidelines.