Research in the Bianco laboratory is divided into three areas. (I) Understanding stalled DNA replication fork rescue. (II) Determining the mechanism of action of the SSB interactome in E.coli and pathogenic bacteria.  (III) Super-resolution imaging of DNA transactions in real-time.

Studies are done in bulk-phase and at the single-molecule level using optical tweezers combined with video-fluorescence microscopy and separately, magnetic tweezers. Super-resolution imaging is combined with our efforts to develop high-speed structured-illumination microscopy.