Saber Tadros, MD

Department Affiliations
Assistant Professor

Interests
Lymphomagenesis
Functional genomics
Spatial Transcriptomics
Machine learning

Education and Training
MD, Cairo University, Medical School, Egypt, 2009 
Postdoctoral Fellow, Lymphoma/Myeloma-Research, MD Anderson Cancer Center, University of Texas, TX, 2018
Research Clinical Fellow, Lymphoid malignancies branch, National Cancer Institute, 2024
Residency, Anatomic Pathology, Laboratory of Pathology, National Cancer Institute, Bethesda, MD, 2021
Fellow, Hematopathology, Laboratory of Pathology, National Cancer Institute, Bethesda, MD, 2024

National Activities
Member, American Society of Clinical Pathology
Member, College of American Pathologist
Member, American Society of Hematology
Member, United States and Canadian Academy of Pathology
Member, Society for Hematopathology
Member, American Association for Cancer Research 

Notable Publications
Sydney R. Stein et al. SARS-CoV-2 infection and persistence across the human body and brain. Nature. 2022 Dec 14:1-6.

Tadros S, Shukla SK, King RJ, Gunda V, Vernucci E, Abrego J, Chaika NV, Yu F, Lazenby AJ, Berim L, Grem J, Sasson AR, Singh PK. “De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer.” Cancer Res. 2017 Oct 15;77(20):5503-5517.

Dominguez PM, Ghamlouch H, Rosikiewicz W, Kumar P, Béguelin W, Fontán L, Rivas MA,Pawlikowska P, Armand M, Mouly E, Torres-Martin M, Doane AS, Calvo Fernandez MT, Durant M, Della-Valle V, Teater M, Cimmino L, Droin N, Tadros S, Motanagh S, Shih AH,Rubin MA, Tam W, Aifantis I, Levine RL, Elemento O, Inghirami G, Green MR, Figueroa ME, Bernard OA, Aoufouchi S, Li S, Shaknovich R, Melnick AM. TET2 Deficiency CausesGerminal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis. Cancer Discov. 2018 Dec;8(12):1632-1653.

Mondello P*, Tadros S*, Jain N, Chan Q, Melnick A, Green M. Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphoma. Cancer Discov. 10.3 (2020): 440-459. *Contributed equally.

García-Ramírez I, Tadros S, González-Herrero I, Martín-Lorenzo A, Rodríguez- HernándezG, Moore D, Ruiz-Roca L, Blanco O, Alonso-López D, Rivas JL, Hartert K, Duval R, Klinkebiel D, Bast M, Vose J, Lunning M, Fu K, Greiner T, Rodrigues-Lima F, Jiménez R, Criado FJG, Cenador MBG, Brindle P, Vicente-Dueñas C, Alizadeh A, Sánchez-García I, Green MR. “Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.” Blood. 2017 May 11;129(19):2645-2656.

Ma MCJ*, Tadros S*, Bouska A, Heavican T, …, Michael R. Green. Subtype-specific and co- occurring genetic alterations in B-cell non-Hodgkin lymphoma. Haematologica. 2022 Mar 1;107(3):690. *Contributed equally.

Jain N*, Hartert K*, Tadros S*, Bouska A, Moore D, Heavican T, Pak C, Green M. "Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in diffuse large B cell lymphoma". Science Translational Medicine 11.497 (2019): eaav5599. *Contributed equally.

Choi J, Lee K, Ingvarsdottir K, Bonasio R, Saraf A, Florens L, Washburn MP, Tadros S, Green MR, Busino L. “Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2.” Nat Cell Biol. 2018 May;20(5):586-596.

Gebregiworgis T, Purohit V, Shukla SK, Tadros S, Chaika NV, Abrego J, Mulder SE, Gunda V, Singh PK, Powers R. “Glucose Limitation Alters Glutamine Metabolism in MUC1- Overexpressing Pancreatic Cancer Cells.” J Proteome Res. 2017 Oct 6;16(10):3536- 3546.

Manion M, Boulougoura A, Naqvi N, Lage SL, Richards E, Grivas C, Laidlaw E, Kuriakose S, Ortega-Villa A, Tadros S, Roby G, Rupert A, Galindo F, Anderson M, Pau A, Deepe G, Sheikh V, Sereti I. Polyfunctional antigen specific CD4+ T cell responses in Patients with HIV/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome. Clin Infect Dis. 2022 Jun 29.

Detailed list of publications.