Yolande Chan, PhD | Pathology, Microbiology, and Immunology | University of Nebraska Medical Center

Department Affiliations
Assistant Professor
Associate Director of Clinical Microbiology

Interests
Clinical Microbiology

Education and Training
BA, Biology, (magna cum laude with Departmental Honors), Barnard College-Columbia University, New York, NY, 2000
PhD, Microbiology, University of Wisconsin-Madison, WI, 2009
Fellow, Clinical Microbiology, University of Nebraska Medical Center, 2024

Notable Publications
Schaub R E, Chan YA, Lee M, Hesek D, Mobashery S, Dillard JP. (2016). Lytic transglycosylases LtgA and LtgD perform distinct roles in remodeling, recycling and releasing peptidoglycan in Neisseria gonorrhoeae. Molecular Microbiology, 102(5), 865-881.

Kohler P L, Chan YA, Hackett KT, Turner N, Hamilton H L, Cloud-Hansen KA, Dillard JP. (2013). Mating pair formation homologue TraG is a variable membrane protein essential for contact-independent type IV secretion of chromosomal DNA by Neisseria gonorrhoeae. Journal of Bacteriology, 195(8), 1666-1679.

Chan YA, Hackett KT, Dillard JP. (2012).The lytic transglycosylases of Neisseria gonorrhoeae. Microbial Drug Resistance, 18(3), 271-279.

Chan YA, *Stohl EA, Hackett KT, Kohler PL, Dillard JP, Seifert HS. (2012). Neisseria gonorrhoeae virulence factor NG1686 is a bifunctional M23B family metallopeptidase that influences resistance to hydrogen peroxide and colony morphology. Journal of Biological Chemistry, 287(14), 11222-11233. (*co-first author)

Chan YA, Thomas MG. (2010). Recognition of (2S)-aminomalonyl-acyl carrier protein (ACP) and (2R)hydroxymalonyl-ACP by acyltransferases in zwittermicin A biosynthesis. Biochemistry, 49(17), 3667-3677.

Chan YA, Podevels AM, Kevany BM, Thomas MG. (2009). Biosynthesis of polyketide synthase extender units. Natural Product Reports, 26(1), 90-114.

Chan YA, Thomas MG. (2009). Formation and characterization of acyl carrier protein-linked polyketide synthase extender units. Methods in Enzymology, 459, 143-163.

Felnagle EA, Jackson EE, Chan YA, Podevels AM, Berti AD, McMahon MD, Thomas MG. (2008) Nonribosomal peptide synthetases involved in the production of medically relevant natural products. Molecular Pharmaceutics, 5(2), 191-211.

Chan YA, Boyne MT 2nd, Podevels AM, Klimowicz AK, Handelsman J, Kelleher NL, Thomas MG. (2006). Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units. Proceedings of the National Academy of Sciences USA, 103(39), 14349-14354.

Thomas MG, Chan YA, Ozanick SG. (2003). Deciphering tuberactinomycin biosynthesis: isolation, sequencing, and annotation of the viomycin biosynthetic gene cluster. Antimicrobial Agents and Chemotherapy, 47(9), 2823-2830.

Bandyopadhyay P, Byrne B, Chan Y, Swanson MS, Steinman HM. (2003). Legionella pneumophila catalase-peroxidases are required for proper trafficking and growth in primary macrophages. Infection and Immunity, 71(8), 4526-4535.