Alfred L.M. Bothwell, PhD

Department Affiliations
Professor

Interests
Immunology
Graduate education

Education and Training
AB (cum laude), Biology, Washington University, St. Louis, MO, 1971
PhD, Biology, Yale University, New Haven, CT, 1975

National Activities
American Association of Immunologists, AAAS, New York Academy of Sciences 
American Society for Microbiology, Society of Sigma Xi 

Notable Publications
Jayakumar A and Bothwell ALM. (2019). Functional diversity of MDSC subsets: the multitasking Hydra of cancer.  J. Immunol. 203:1095-1103, PMC6703177, PMID 31427398.

Shin JH, Jeong J, Choi J, Lim J, Dinesh RK, Braverman J, Hong JY, Maher SE, Amezcua Vesely MC, Kim W, Koo JH, Tang W, Wu D, Blackburn HN, Xicola RM, Llor X, Yilmaz O, Choi JM and Bothwell ALM. (2021). Dickkopf-2 regulates the stem cell marker Lgr5 and differentiation of colorectal cancer cells via HNF4α1. iScience, 24:102411, PMID 33997693, PMC8099562.

van den Pol A, Zhang X, Maher SE and Bothwell ALM. Immune cells enhance Zika virus-mediated neurologic dysfunction in brain of mice with humanized immune system. (2021). Dev. Neurobiol. 81:389-399, PMID 33811750, doi.org/10.1002/dneu.22820.

Palura SL, Burak M, Senejani AG, Carufe K, Clairmont K, Alvarado-Cruz I, Meas R, Kashgarian M, Zeiss C, Maher SE, Bothwell ALM, Dizderoglou M, Lloyd RS and Sweasy JB. (2021). DNA Glycosylase Deficiency Leads to Decreased Severity of Lupus in the Polb-Y265C Mouse Model. DNA Repair. 105:103152, PMID: 34186496.

Shin H, Jeong J, Maher SE, Lee HW and Bothwell ALM. (2021). Cancer cells acquired membrane proteins from tumor-infiltrating lymphocytes by trogocytosis. Proc. Natl. Acad. Sci. USA, 118, e2110241118 (2021).

Park MH, Shin JH, Bothwell ALM and Chae WJ. (2022). Dickkopf proteins in pathological inflammatory diseases.  J. Leuk. Biol., doi.org/10.1002/JLB.3RI0721-385R.

Lee S, Cavaliere A, Gallezot JD, Keler T, Michelhaugh S, Belitzky E, Liu M, Mulnix T, Maher SE,  Bothwell ALM, Li F, Phadke M,  Mittal S and Marquez-Nostra B. (2022).  [⁸⁹Zr]ZrDFO-CR011 Positron Emission Tomography Correlates with Response to Glycoprotein Non-metastatic Melanoma B-targeted Therapy in Triple-Negative Breast Cancer. Molecular Cancer Therapeutics, Jan 13;molcanther.0590.2021. doi: 10.1158/1535-7163.MCT-21-0590. PMID 35027482.

Rahim T, Madison A, Levinson MA, Carufe K, Burak M, Meas R, Maher SE, Bothwell ALM, Gades N and Sweasy JB. (2022). The Hematopoietic Compartment is Sufficient for Lupus Development Resulting from the POLB-Y265C Mutation. Plos One 17(4): e0267913. 

Ihedioha OC, Sivakoses A, Beverley SM, McMahon-Pratt D and Bothwell ALM. (2023). Leishmania major-derived lipophosphoglycan influences the host’s early immune response by inducing platelet activation and DKK1 production via TLR2. Frontiers in Immunology, DOI 10.3389/fimmu.2023.1257046.