Workshop Schedule

Monday, August 1, 2022

7:30 – 8:45 a.m.   Registration & Breakfast
    Location: Durham Research Center
8:45 – 9:00 a.m.   Welcome
    Yuri Lyubchenko (UNMC) and Mohtadin Hashemi (UNMC)
 9:00 – 9:10 a.m.   Opening Remarks
    Jennifer Larsen, UNMC Vice Chancellor for Research
     

Session I: “Molecular Structures and Conformations I – Single Molecule Fluorescence”
9:10 – 9:40 a.m.   Talk 1 (Chair): Maria Spies – University of Iowa
    Title: Replicate, repair, recombine: Conformation dynamics of the Replication Protein A (RPA) in cellular decision making
9:40 – 10:00 a.m.   Talk 2: Sean Carney – University of Illinois at Urbana-Champaign
    Title: Direct measurement of stepping dynamics of E.coli UvrD helicase
10:00 – 10:20 a.m.   Talk 3: Benjamin J. Ryan – University of Kansas Medical Center
    Title: Structural basis for engagement of nucleosomal DNA damage by DNA polymerase β
10:20 – 10:40 a.m.   Talk 4: Gabrielle Perkins – The University of Kansas
    Title: Using single-molecule FRET to study RNA chaperone assisted folding
10:40 – 10:50 a.m.   Break
     

Session II: “Molecular Structures and Conformations II”

10:50 – 11:20 a.m.   Talk 5 (Chair): Sua Myong – Johns Hopkins University
    Title: Vectorial folding of telomeric overhang increases accessibility
11:20 – 11:40 a.m.   Talk 6: Bianca Chavez – University of Wisconsin-Madison
    Title: Telomere-loop regulation by shelterin complexes
11:40 – 12:00 p.m.   Talk 7: Li-Chun Tu – The Ohio State University
    Title: Single chromosome dynamics and chromosome territory orientation revealed by CRISPR-based live-cell imaging
12:00 – 12:30 p.m.   Talk 8 (Invited): Jingyi Fei - The University of Chicago
    Title: Dynamic interplay between sRNA, mRNA, and their chaperone in bacteria
12:30 – 1:00 p.m.   Sponsor Talk: LUMICKS
1:00 – 2:30 p.m.   Lunch & Learn Sessions with Vendors/Poster Preview 
2:00 – 2:30 p.m.   Roundtable Discussion
    (Students, Invited Speakers)
2:30 – 4:00 p.m.   Poster Session
    Location: UNMC Durham Research Center II Commons
     

Session III: “Computational Modeling and Theory”
4:00 – 4:30 p.m.   Talk 9 (Chair): Tobin Sosnick – University of Chicago
    Title: Simulations of the force-induced unfolding of membrane proteins find that AFM and tweezers sample different energy surfaces
4:30 – 4:50 p.m.   Talk 10: Ariel Robbins – The Ohio State University
    Title: Design and characterization of a DNA origami force probe
4:50 – 5:10 p.m.   Talk 11: Sabita Sharma – University of Wisconsin-Milwaukee
    Title: The surprising force-response of talin R8 domain, locked into a mechanically stable state by its DLC1 ligand
5:10 – 5:30 p.m.   Talk 12: Arne Gennerich – Albert Einstein College of Medicine
    Title: Single-molecule studies of KIF1A motion and force generation
     

Special Sessions and Keynote Address
6:00 – 7:00 p.m.   Keynote Address: Carlos Bustamante – University of California at Berkeley
    Title: Two single-molecule co-translational protein folding stories
7:00 – 9:00 p.m.   Dinner
    Location: Truhlsen Events Center, Michael F. Sorrell Center for Health Science Education
    Workshop Business Meeting (Organizers, Invited Speakers)

 

Tuesday, August 2, 2022

7:30 – 8:45 a.m.   Breakfast
  Location: Durham Research Center
8:45 – 8:55 a.m. Announcements
8:55 – 9:00 a.m.  Best Poster Award Ceremony – Sponsored by Symmetry 
   

Session IV: "Computational Techniques in Biophysics" 
9:00 – 9:30 a.m.   Talk 13 (Chair): Anatoly Kolomeisky – Rice University
  Title: Stochastic mechanisms of cell-size regulation in bacteria
9:30 – 10:00 a.m. Talk 14 (Invited): Lela Vukovic – The University of Texas at El Paso
  Title: Computational modeling of molecules and nanomaterials for biomedical applications
10:00 – 10:20 a.m. Talk 15: Abhinaw Kumar – The University of Texas at Austin
  Title: Sequence determines the switch in the fibril forming regions in the low-complexity FUS protein and its variants
10:20 – 10:30 a.m. Break
   

Session V: "Combined Single Molecule Methods" 
10:30 – 11:10 a.m.   Talk 16 (Chair): Yale Goldman – University of Pennsylvania
  Title: Mechanism of the stop codon readthrough agent, ataluren, in protein synthesis: Correlation of peptide and tRNA release events from individual ribosomes
11:00 – 11:20 a.m. Talk 17: Liuhan Dai – University of Michigan
  Title: Highly specific, aplication-free, single-molecule counting of rare methylated DNA cancer biomarkers
11:20 – 11:40 a.m. Talk 18: Goldbarg Mohammadiroozbahani – The Ohio State University
  Title: Functionalizing DNA origami assisted nuclear transport in human cells
11:40 – 12:00 p.m. Talk 19: Shizhen Wang – University of Missouri-Kansas City
  Title: Ligand and voltage-gated in a human proton channel hHv1
12:00 – 12:20 p.m. Talk 20: Time I. Peace – University of Leeds
  Title: Single-molecule fingerprinting of amyloid fibrils within a crowded nanopore
12:20 – 12:50 p.m. Sponsor Talk: Mad City Labs
12:50 – 2:00 p.m. Lunch & Learn Sessions with Vendors
   

Session VI: "Atomic Force Microscopy – Single Molecule Imaging and Force Probing"
2:00 – 2:30 p.m.   Talk 21 (Chair): Gavin King – University of Missouri 
  Title: How do proteins get into and across membranes? Precise single molecule measurements provide insights into general secretory system mechanisms
2:30 – 2:50 p.m. Talk 22: Aleksandr Noy – Lawrence Livermore National Laboratory
  Title: High-speed atomic force microscopy of membrane remodeling by dynamin
2:50 – 3:10 p.m. Talk 23: Sridhar Vemulapalli – University of Nebraska Medical Center
  Title: Single molecule probing of the stability of synaptic Sfil-DNA complexes
3:10 – 3:30 p.m. Talk 24: Yaqing Wang – Lawrence Livermore National Laboratory
  Title: Impacts of DNA sequences and internucleosomal interactions on the organization of the nucleosome array
3:30 – 3:55 p.m. Closing Remarks
3:55 – 4:00 p.m. Best Speaker Award Ceremony – sponsored by International Journal of Molecular Sciences

 

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