Balasrinivasa Sajja, PhD
Magnetic resonance imaging-based biomarkers provide invaluable information about disease progression and response to therapeutic interventions. Balasrinivasa Sajja, PhD, has a laboratory that focuses on the development of methods and applications of quantitative MRI, including relaxometry, diffusion tensor imaging, magnetic resonance spectroscopy and perfusion MRI, to investigate image-based measures detecting structural, functional and metabolic alterations caused by disease and treatment.
His research has developed an automated magnetic resonance spectroscopy imaging quantification approach for in vivo brain metabolites measurement and robust image processing methods for detecting and segmenting multiple sclerosis lesions. His lab is involved in studies that quantify the biodistribution of MR-sensitive nanomaterials such as superparamagnetic iron oxide in mouse and rat models of HIV and cancer. Other successes include the creation of an in vivo manganese-enhanced MRI mouse brain atlas for whole-brain longitudinal morphological studies and brain pathology during progressive HIV-1 infection. Tumor perfusion in pancreatic cancer studies was successfully measured using dynamic contrast-enhanced MRI. As the image analysis lead at the Bioimaging Core Facility at UNMC, Dr. Sajja collaborates with multiple researchers and supports MRI processing in clinical and preclinical studies to meet their research needs.
Publications
- Long-acting dolutegravir formulations prevent neurodevelopmental impairments in a mouse model, Dec 2023, Frontiers in Pharmacology
- Endothelin-axis antagonism enhances tumor perfusion in pancreatic cancer, Sep 2022, Cancer Letters
- Individual and cumulative measures of knee joint load associate with T2 relaxation times of knee cartilage in young, uninjured individuals: A pilot study, Aug 2021, The Knee
- Generation and Disease Model Relevance of a Manganese Enhanced Magnetic Resonance Imaging-Based NOD/scid-IL-2Rγc(null) Mouse Brain Atlas, Nov 2015, Journal of Neuroimmune Pharmacology
- Longitudinal magnetic resonance spectroscopic imaging of primary progressive multiple sclerosis patients treated with glatiramer acetate: multicenter study, Jan 2008, Multiple Sclerosis
Find a complete list of Dr. Sajja's publications on PubMed.
