Kaushik P. Patel, PhD
A. Ross McIntyre Professor of Physiology
Professor, UNMC Department of Cellular and Integrative Physiology
Kaushik P. Patel, PhD, is an endowed A. Ross McIntyre Professor of Physiology in the UNMC Department of Cellular & Integrative Physiology. He has active research funded by the National Institutes of Health and the National Strategic Research Institute.
Dr. Patel is active in the education of medical and graduate students, , as well as post-doctoral training at UNMC.
Dr. Patel's lab studies various aspects of the blood volume regulation in normal and disease states such as heart failure, hypertension and diabetes.
Biochemical, molecular biology, electrophysiological, hemodynamic and renal function measurements and techniques are used for studying the various components of the blood volume reflex arc with particularly emphasis on role the paraventricular nucleus of the hypothalamus in this regulation.
Current work is focused on renal afferents and their influence on the sympathetic outflow in disease conditions such as heart failure. These studies are providing important new insights about the normal neural regulation of fluid balance and about altered fluid balance and its consequences in various disease states.
- Bachelor's: University of Toronto, Ontario, Canada; physiology and pharmacology, with honors, 1978
- Master's: University of Western Ontario, London, Ontario, Canada; physiology, 1980
- PhD: University of Western Ontario, London, Ontario, Canada; physiology, 1983
- Postdoctoral Fellow: University of Iowa, Iowa City; cardiology, 1984-87
Focus: Neural regulation of cardiovascular and renal function in health and disease states.
Lab: Various aspects of the blood volume regulation in normal and disease states such as heart failure, hypertension and diabetes.
Current work: Renal afferents and their influence on the sympathetic outflow in disease conditions such as heart failure.
Proposed model for the neural and humoral connection between the heart and the kidneys via the central nervous system and the potential therapeutic target sites in cardiorenal syndrome.
- Patel KP, Xu B, Liu X, Sharma NM, Zheng H. Renal Denervation Improves Exaggerated Sympathoexcitation in Rats With Heart Failure: A Role for Neuronal Nitric Oxide Synthase in the Paraventricular Nucleus. Hypertension. 2016 Jul;68(1):175-84. doi: 10.1161/HYPERTENSIONAHA.115.06794. Epub 2016 May 16. PubMed PMID: 27185748; PubMed Central PMCID: PMC4900899.
- Zheng H, Patel KP. Integration of renal sensory afferents at the level of the paraventricular nucleus dictating sympathetic outflow. Auton Neurosci. 2017 May;204:57-64. doi: 10.1016/j.autneu.2016.08.008. Epub 2016 Aug 6. Review. PubMed PMID: 27527558; PubMed Central PMCID: PMC5293680.
- Katsurada K, Nandi SS, Sharma NM, Patel KP. Enhanced Expression and Function of Renal SGLT2 (Sodium-Glucose Cotransporter 2) in Heart Failure: Role of Renal Nerves. Circ Heart Fail. 2021 Dec;14(12):e008365. doi: 10.1161/CIRCHEARTFAILURE.121.008365. Epub 2021 Nov 18. PubMed PMID: 34789005; PubMed Central PMCID: PMC8692398.
- Patel KP, Katsurada K, Zheng H. Cardiorenal Syndrome: The Role of Neural Connections Between the Heart and the Kidneys. Circ Res. 2022 May 13;130(10):1601-1617. doi: 10.1161/CIRCRESAHA.122.319989. Epub 2022 May 12. Review. PubMed PMID: 35549375; PubMed Central PMCID: PMC9179008.
Full list of publications, National Library of Medicine.