Biophysics PhD Track
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Time-lapse Atomic Force Microscopy images illustrating the movement of SfiI enzyme (bright particle) along the DNA filament.
Broad research areas include: (1) Structural genomics in relation to cancer, (2) Molecular mechanisms of Alzheimer’s, Parkinson’s and other protein aggregation diseases, (3) Protein-DNA interactions for novel approaches for HIV restriction, (4) Development of novel nanoimaging and nanoprobing approaches.
An additional focus is on the molecular forces that control the conformational stability and flexibility of nucleic acids, and the interaction of ligands (including clinical agents) with nucleic acids as a function of binding mode, nucleic acid conformation, sequence specificity, and solution conditions. Lastly, the role of water on the conformational stability of biomolecules is being studied by examining sequence hydration effects in nucleic acids, drug-nucleic acid complexes, DNA covalent adducts and protein-DNA interactions.
College of Pharmacy Pharmaceutical Sciences Graduate Program at UNMC- Biophysics Feature
Biophysics Faculty
Professor, UNMC Department of Pharmaceutical Sciences
402-559-1971
402-559-5673
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Professor, UNMC Department of Pharmaceutical Sciences
Director, Pharmaceutical Sciences Graduate Program
402-559-4628
402-559-5673
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Professor, UNMC Department of Pharmaceutical Sciences
402-559-6293
402-559-5673
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