Christopher L Shaffer, PharmD, PhD, MS
Associate Professor, UNMC Department of Pharmacy Practice and Science
Director, Pediatric Clinical Pharmacology Program, Child Health Research Institute
402-559-4333
402-559-5060
Research Activities/Interests
Dr. Shaffer’s is Director of the Pediatric Clinical Pharmacology Program within the Child Health Research Institute. The Pediatric Clinical Pharmacology Program translates pediatric pharmacokinetic, pharmacodynamic and pharmacogenomic research into clinical practice. As a collaboration between the UNMC Colleges of Pharmacy and Medicine, Children’s Hospital & Medical Center and CHRI, the goal of the program is to work in partnership to study and optimize medication therapy in pediatric patients.
The Pediatric Clinical Pharmacology Program is comprised of the Pediatric Pharmacology Research Unit (PPRU), along with a Clinical Pharmacology Consult Service. The PPRU is capable of developing non-traditional drug assays, pharmacokinetic/pharmacodynamics modeling and clinical trial design and support. The PPRU is currently working with clinicians, academic researchers, federal/industry sponsors and private donors to better understand the relationship between pharmacology and ontogeny in the pediatric patient population. In addition, the Program offers a Clinical Pharmacology Consult Service that can assist clinicians and patients that have suffered therapeutic toxicities or treatment failures. One component of this therapeutic assessment is the partnership with UNMC Genetic Medicine in the formation of the Pharmacogenetics Clinic at MMI. The clinic is a multi-disciplinary team of geneticists, genetic counselors and clinical pharmacologists who examine the relationship between genetics and pharmacology to recommend a “personalized medicine” approach for patients and clinicians.
The Pediatric Clinical Pharmacology Program is comprised of the Pediatric Pharmacology Research Unit (PPRU), along with a Clinical Pharmacology Consult Service. The PPRU is capable of developing non-traditional drug assays, pharmacokinetic/pharmacodynamics modeling and clinical trial design and support. The PPRU is currently working with clinicians, academic researchers, federal/industry sponsors and private donors to better understand the relationship between pharmacology and ontogeny in the pediatric patient population. In addition, the Program offers a Clinical Pharmacology Consult Service that can assist clinicians and patients that have suffered therapeutic toxicities or treatment failures. One component of this therapeutic assessment is the partnership with UNMC Genetic Medicine in the formation of the Pharmacogenetics Clinic at MMI. The clinic is a multi-disciplinary team of geneticists, genetic counselors and clinical pharmacologists who examine the relationship between genetics and pharmacology to recommend a “personalized medicine” approach for patients and clinicians.
Teaching Activities
Dr. Shaffer is course coordinator for Pharmacogenomics and Pediatrics. In addition, he provides lectures in team-taught courses in Pharmacotherapy, Pharmaceutical Sciences, and other classes throughout the UNMC campus.