Natalia Osna, MD, PhD
Education
- MD, Riga's Medical Institute (Latvian Medical Academy), Latvia, 1978
- PhD in Immunology, Latvian Center of Hepatology, Latvia 1984
Memberships
- American Association of the Study of Liver Diseases (currently, AASLD Fellow)
- International Society for Biomedical Research on Alcohol
- European Society for Biomedical Research on Alcohol
- American Association of Immunologists
- International Society for Extracellular Vesicles
Recognition
- The Innovation Award (New Invention notification), 2010, UNMC, Omaha, NE
- Basic Science Investigator Award, Internal Medicine Department, 2014, UNMC, Omaha, NE
- New Investigator Award, 2014, UNMC, Omaha, NE
- 8th International, Congress of Immunology, Budapest, 1992;
- VI International Symposium on Viral Hepatitis, Madrid, 1994;
- 30th Annual EASL (EUROHEP) Meeting, Copenhagen, 1995;
- 9th International Congress of Immunology, San Francisco, 1995;
- 31st EASL Meeting, Geneva, 1996;
- AASLD Single Topic Conference Human Liver Cells in Biomedical Research, Warrenton, VA, 2002
- RsoA Satellite Symposium, Baltimore, 2006
- RsoA Satellite Symposium, Washington DC, 2008;
- ISBRA Meeting, Paris, France, 2010
- ISBRA Meeting, Kyoto, Japan, 2018
- 2018 Best Paper Award: from Topical Collection: Alcohol-related organ damage, Biomolecules
- 2022- Recognition as Expertscape World Expert in Ethanol and Alcohol-related disorders (top 1% of scholars writing on these topics)
Selected Publications
- Moses New-Aaron, Siva Sankar Koganti, Murali Ganesan, Sharma Kanika, Vikas Kumar, Weimin Wang, Edward Makarov, Kusum K. Kharbanda, Larisa Y. Poluektova and Natalia A. Osna. Hepatocyte-Specific Triggering of Hepatic Stellate Cell Profibrotic Activation by Apoptotic Bodies: The Role of Hepatoma-Derived Growth Factor, HIV, and Ethanol. J. Mol. Sci. 2023, 24, 5346. https://doi.org/10.3390/ijms24065346
- Srijanee Das†, Weimin Wang†, Murali Ganesan†, Franchesca Fonseca-Lanza,Denise A. Cobb, Grace Bybee, Yimin Sun, Lili Guo, Brandon Hanson, Samuel M. Cohen, ,Howard E. Gendelman, Natalia A. Osna*, Benson J. Edagwa*, Larisa Y. Poluektova*An ultralong-acting tenofovir ProTide nanoformulation achieves monthslong HBV suppression. Adv. 8, eade9582 (2022) 23 December 2022, PMID: 36563152; PMCID: PMC9788773
- Natalia A. Osna, Akiko Eguchi, Ariel E. Feldstein, Hidekazu Tsukamoto, Raghubendra S. Dagur, Murali Ganesan, Moses New-Aaron, Madan Kumar Arumugam, Srinivas Chava, Marcelle Ribeiro, Gyongyi Szabo, Sebastian Mueller, Shijin Wang, Cheng Chen, Steven A. Weinman and Kusum K. Kharbanda Cell-to-Cell Communications in Alcohol-Associated Liver Disease. Physiol., 21 February 2022 https://doi.org/10.3389/fphys.2022.831004 PMID: 35264978
- Ganesan M, Wang W, Mathews S, Makarov E, New-Aaron M, Dagur RS, Malo A, Protzer U, Kharbanda KK, Casey CA, Poluektova LY, Osna NA. Ethanol attenuates presentation of cytotoxic T-lymphocyte epitopes on hepatocytes of HBV-infected humanized mice Alcohol Clin Exp Res. 2021 Nov 13. doi: 10.1111/acer.14740. PMID: 3477326
- Murali Ganesan, Moses New-Aaron, Raghubendra Singh Dagur, Edward Makarov, Weimin Wang, Kusum Kharbanda, Srivatsan Kidambi, Larisa Poluektova, Natalia Osna. Alcohol Metabolism Potentiates HIV-Induced Hepatotoxicity: Contribution to End-Stage Liver Disease. Biomolecules 2019, 9, 851; doi: 10.3390/biom9120851; PMID: 31835520
- Murali Ganesan, Irina Tikhanovich, Shiva Shankar Vangimalla, Raghubendra Singh Dagur, Weimin Wang, Larisa I. Poluektova, Yimin Sun, David F. Mercer, Dean Tuma, Steven A. Weinman, Kusum K. Kharbanda, Natalia A. Osna. Demethylase JMJD6 as a new regulator of interferon signaling: effects of HCV and ethanol metabolism. Cell Mol Gastroenterol Hepatol 2018; 5:101–112, PMID:
- Ganesan M, Hindman J, Tillman B, Jaramillo L, Poluektova LI, French BA, Kharbanda KK, French SW, Osna NA. FAT10 suppression stabilizes oxidized proteins in liver cells: Effects of HCV and ethanol. Exp Mol Pathol. 2015 Sep 25;99(3):506-516
- Zhang J, Garrison JC, Poluektova LY, Bronich TK, Osna NA. Liver-targeted antiviral peptide nanocomplexes as potential anti-HCV therapeutics. 2015 Nov;70:37-47
- Osna, NA, White, RL, Krutik, VM, Wang, T, Weinman, SA, Donohue, TM. Proteasome Activation by Hepatitis C Core Protein is Reversed by Ethanol-Induced Oxidative Stress. Gastroenterology 2008; 134:2144-2152.
- Osna N, White R, Todero S, McVicker B, Thiele G, Clemens D, Tuma D, Donohue T. Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells. Hepatology, 2007;45: 53-62.