College of Medicine

- Admissions Overview
- - MD Program
    UNMC's rigorous academics, diverse clinical experiences and supportive environment put you on the path to becoming a skilled, compassionate physician.
  - How to Apply
    UNMC prepares medical degree students to meet the needs of patients through clinical practice, biomedical science and research, problem-solving and compassion.
  - Contact Us
    Review contact information for the Office of Admissions and Student Affairs in the College of Medicine at UNMC.
  - Verification and State Licensure
    Review opportunities for state licensure following completion of the MD program in the College of Medicine at UNMC.
- - MD-MBA Program
    A combined MD-MBA degree equips you with the tools you need to become highly skilled in both management and medicine.
  - MD-MPH Program
    Pursue your passion for public health and medicine with a combined MD-MPH and help solve complex health problems.
  - MD-PhD Program
    Do you have a passion for caring for patients and for research? Consider the dual MD-PhD degree.
- Education Overview
- - Curriculum
    Our curriculum produces physicians whose foundation in basic, clinical, and health systems sciences prepare them to promote health and reduce patient suffering.
  - Graduation Requirements
    Review requirements for students pursuing an MD at the UNMC College of Medicine to graduate and receive their degree.
  - Objectives
    The objectives of UNMC's medical degree program are to prepare you for success in primary care or specialty fields.
  - Service Learning
    Active participation in community service provides critical opportunities to apply skills and knowledge gained in medical school and develop a sense of empathy.
- - Enhanced Medical Education
    Enhanced Medical Education Tracks offer medical students an opportunity to perform an in-depth study of an interdisciplinary field of medicine.
  - Enhanced Medical Education Tracks
    EMET applicants are selected for Tracks based on their interest in the topic and motivation to complete work above and beyond the primary MD curriculum.
  - MD Honor’s Thesis Program
    The MD honors thesis encourages students to engage in scientific research during medical education and become eligible to graduate with honors.
- Research Overview
- Internal Grants
  The College of Medicine has a variety of research-related grant and award opportunities available to UNMC faculty.
- Comparative Effectiveness Research
  The Comparative Effectiveness Research (CER) program identifies knowledge gaps in the effectiveness of clinical care and improves CER in these areas.
- Great Plains IDeA-CTR
  The Great Plains IDeA-CTR is a collaborative effort between nine regional institutions that provides training, resources. and funding to regional researchers.
- Research and Development Committee
  The Research and Development Committee handles funding opportunities for faculty, including the Bridge Funding program, and student research opportunities.
- Student Opportunities
  The College of Medicine provides a variety of research opportunities for both current and prospective UNMC students.
- Residencies & Fellowships Overview
- Graduate Medical Education Programs
  UNMC's dozens of programs--including nearly 20 in internal medicine--allow residents and fellows a variety of specialties.
- House Officer Resources
  Find information for residents and fellows, including salaries, benefits and nearby housing.
- House Officer Wellness
  Wellness resources for residents and fellows include an assistance program and a private wellness lounge.
- Research
  We aim to facilitate house officers’ involvement in research in the areas of patient safety, quality improvement, healthcare disparities and education research.
- Salary and Benefits
  Paid vacation and professional leave, health insurance and meal allowances are just a few of the benefits residents receive in addition to their yearly salary.
- Contact Us
  Reach out to the Graduate Medical Education office for information about benefits, contracts, orientation or graduation.
Departments

— College of Medicine — Department of Pharmacology and Experimental Neuroscience — Faculty — Instructors — Sudipta Panja, PhD

Sudipta Panja, PhD

Instructor

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Laboratory of Howard E. Gendelman, MD

Sudipta Panja, PhD

Research Interests

My research interest is the development of new nanomedicine for targeted drug/ gene delivery. My current research is focused on developing a lipid nanoparticle (LNP)-based CRISPR-Cas9 delivery system to eliminate the parvoviral DNA from the HIV-1 reservoir. Since HIV-1 reservoirs have a significant number of CXCR4/ CCR5-like chemokine receptors, LNP ornamented with CXCR4/ CCR5-ligands can efficiently target the HIV-1 reservoir. Therefore, we sought to develop CXCR4/ CCR5-ligand ornamented LNPs with an adequate lipid composition to maximize the CRISPR-Cas9 encapsulation and receptor-specific delivery to the reservoir. This advanced approach will increase the therapeutic performance of LNPs by reducing off-target toxicities.

Ongoing Projects

Development of a CXCR4/ CCR5-targeted LNP

In the CRISPR-Cas9 therapy, we deliver Cas9 mRNA and guide mRNA together. The mRNA-delivering LNP fundamentally has four components, ionizable lipid, sitosterol, helper lipid, and PEG-lipid. In the first step, we modify the PEG-lipid by synthesizing CXCR4/ CCR5-ligands conjugated PEG-lipids. Next, the modified PEG-lipids are integrated into the LNP to achieve a colloidally stable targeted LNP (T-LNP) with high mRNA encapsulation efficiency. The therapeutic performance of T-LNP to eliminate the proviral DNA from the lately infected T cells is being evaluated in in vitro and in vivo settings.

Education

PhD, Polymer Nanomaterials, 2016, Indian Institute of Technology, Kharagpur, India

Memberships

2022–Present Associate Editor, International Journal of Nano and Biomaterials
2022–Present Review Editor, Frontiers in Pharmacology
2022–Present Editorial Board Member, Biopolymers Research
2021–Present Guest Editorial for the special issue, Polymer
2021–Present Review Editor, Frontiers in Biomaterials Science
2022–Present Guest Associate Editor, Biomedical Nanotechnology

Recognition

2011 Junior Research Fellowship of CSIR-UGC, India
2013 Best oral presentation award at International Conference of Polymer Quest-2013, at IIT Kharagpur, India
2013 Senior Research Fellowship of CSIR-UGC, India