Guoku Hu, PhD
Associate Professor, UNMC Department of Pharmacology and Experimental Neuroscience

Guoku Hu, PhD, is an associate professor in the UNMC Department of Pharmacology and Experimental Neuroscience. His research interests center on neurodegenerative diseases, specifically substance-use disorders, Alzheimer's disease and Parkinson's disease, with a unique emphasis on understanding the roles of extracellular vesicles and primary cilia in these pathologies.
- PhD in Genetics, Sichuan University, Chengdu, China, 2006
Neurodegenerative diseases, substance use disorders, Alzheimer's disease, Parkinson's disease and extracellular vesicles primary cilia.
- Ma R*, Kutchy NA, Wang Z, Hu G*. Extracellular vesicle-mediated delivery of anti-miR-106b inhibits morphine-induced primary ciliogenesis in the brain. Molecular Therapy. 2023 May 3;31(5):1332-1345. doi: 10.1016/j.ymthe.2023.03.030. Epub 2023 Apr 3. PMID: 37012704.
- Ma R, Kutchy NA, Hu G*. Astrocyte-Derived Extracellular Vesicle-Mediated Activation of Primary Ciliary Signaling Contributes to the Development of Morphine Tolerance. Biological Psychiatry. 2021 Jun 17:S0006-3223(21)01395-0. doi: 10.1016/j.biopsych.2021.06.009. Online ahead of print. PMID: 34417054.
- Chivero ET*, Dagur RS, Peeples ES, Sil S, Liao K, Ma R, Chen L, Gurumurthy CB, Buch S, Hu G*. Biogenesis, physiological functions and potential applications of extracellular vesicles in substance use disorders. Cellular and Molecular Life Sciences. 2021 Jun;78(11):4849-4865. doi: 10.1007/s00018-021-03824-8. Epub 2021 Apr 5. PMID: 33821293.
- Sil S, Hu G, Liao K, Niu F, Callen S, Periyasamy P, Fox HS, Buch S. HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis. PLOS Biology. 2020 May 26;18(5):e3000660. doi: 10.1371/journal.pbio.3000660. eCollection 2020 May. PMID: 32453744.
- Dagur RS, Liao K, Sil S, Niu F, Sun Z, Lyubchenko YL, Peeples ES, Hu G*, Buch S*. Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats. Journal of Extracellular Vesicles. 2019 Dec 20;9(1):1703249. doi: 10.1080/20013078.2019.1703249. eCollection 2020. PMID: 32002168.
College of Medicine
University of Nebraska Medical Center
Durham Research Center 3013
985880 University of Nebraska Medical Center
Omaha, NE 68198-5800