College of Medicine

- Admissions Overview
- - MD Program
    UNMC's rigorous academics, diverse clinical experiences and supportive environment put you on the path to becoming a skilled, compassionate physician.
  - How to Apply
    UNMC prepares medical degree students to meet the needs of patients through clinical practice, biomedical science and research, problem-solving and compassion.
  - Contact Us
    Review contact information for the Office of Admissions and Student Affairs in the College of Medicine at UNMC.
  - Verification and State Licensure
    Review opportunities for state licensure following completion of the MD program in the College of Medicine at UNMC.
- - MD-MBA Program
    A combined MD-MBA degree equips you with the tools you need to become highly skilled in both management and medicine.
  - MD-MPH Program
    Pursue your passion for public health and medicine with a combined MD-MPH and help solve complex health problems.
  - MD-PhD Program
    Do you have a passion for caring for patients and for research? Consider the dual MD-PhD degree.
- Education Overview
- - Curriculum
    Our curriculum produces physicians whose foundation in basic, clinical, and health systems sciences prepare them to promote health and reduce patient suffering.
  - Graduation Requirements
    Review requirements for students pursuing an MD at the UNMC College of Medicine to graduate and receive their degree.
  - Objectives
    The objectives of UNMC's medical degree program are to prepare you for success in primary care or specialty fields.
  - Service Learning
    Active participation in community service provides critical opportunities to apply skills and knowledge gained in medical school and develop a sense of empathy.
- - Enhanced Medical Education
    Enhanced Medical Education Tracks offer medical students an opportunity to perform an in-depth study of an interdisciplinary field of medicine.
  - Enhanced Medical Education Tracks
    EMET applicants are selected for Tracks based on their interest in the topic and motivation to complete work above and beyond the primary MD curriculum.
  - MD Honor’s Thesis Program
    The MD honors thesis encourages students to engage in scientific research during medical education and become eligible to graduate with honors.
- Research Overview
- Internal Grants
  The College of Medicine has a variety of research-related grant and award opportunities available to UNMC faculty.
- Comparative Effectiveness Research
  The Comparative Effectiveness Research (CER) program identifies knowledge gaps in the effectiveness of clinical care and improves CER in these areas.
- Great Plains IDeA-CTR
  The Great Plains IDeA-CTR is a collaborative effort between nine regional institutions that provides training, resources. and funding to regional researchers.
- Research and Development Committee
  The Research and Development Committee handles funding opportunities for faculty, including the Bridge Funding program, and student research opportunities.
- Student Opportunities
  The College of Medicine provides a variety of research opportunities for both current and prospective UNMC students.
- Residencies & Fellowships Overview
- Graduate Medical Education Programs
  UNMC's dozens of programs--including nearly 20 in internal medicine--allow residents and fellows a variety of specialties.
- House Officer Resources
  Find information for residents and fellows, including salaries, benefits and nearby housing.
- House Officer Wellness
  Wellness resources for residents and fellows include an assistance program and a private wellness lounge.
- Research
  We aim to facilitate house officers’ involvement in research in the areas of patient safety, quality improvement, healthcare disparities and education research.
- Salary and Benefits
  Paid vacation and professional leave, health insurance and meal allowances are just a few of the benefits residents receive in addition to their yearly salary.
- Contact Us
  Reach out to the Graduate Medical Education office for information about benefits, contracts, orientation or graduation.
Departments

— College of Medicine — Department of Obstetrics and Gynecology — Research — Academic Research — Shyamal Roy, PhD - Lab

Shyamal Roy, PhD - Lab

Shyamal Roy, PhD

Learn More About Dr. Roy

Shyamal Roy, PhD, has a research focus of addressing how estrogen, the most important reproductive hormone in women, affects follicular development at two very critical steps in folliculogenesis.

Roy Lab Members

Shyamal K. Roy, PhD

Professor
Director of the Molecular Reproductive Endocrinology Laboratory

Send Email

Phone: 402-559-5445

Shyamal K. Roy, PhD

Research Interests

Project 1

We are studying how estrogen, epidermal growth factor, and transforming growth factor beta interact to bring about antral follicle development. Antral follicles are recruited by follicle-stimulating hormones for ovulation; hence, this transition step is critical for successful folliculogenesis and ovulation. We are investigating how classic estrogen receptor-b mediates estrogen-induced proliferation of granulosa cells as well as induces estrogen receptor-a in the granulosa cells of immature ovarian follicles. Estrogen via estrogen receptor-a stimulates the expression of epidermal growth factor receptor and transforming growth factor beta receptor. We contend that once activated, these receptors initiate intracellular signals that lead to the maturation of granulosa cells within the ovarian follicle. This finely tuned process involves feedback control circuits between estrogen receptors and the growth factor receptors and is crucial for the successful development of preovulatory follicles.

Project 2

The focus of this project is on the mechanism of estrogen-mediated primordial follicle formation. Primordial follicles form the first cohort of follicles that determine the fecundity in mammalian females, including women. We contend that undifferentiated somatic cells in the ovary are transformed into epithelial granulosa cells by an estrogen-mediated PI3kinase signaling mechanism. We use a variety of molecular and cellular approaches to determine the morphogenesis of primordial follicles. The results may offer means to improve fertility in women, whose ovarian follicles do not respond to gonadotropins for whatever reason and also may provide new insight into the mechanisms of primordial follicle formation and development.