Kendra Clark, PhD

Assistant Professor
Department of Obstetrics and Gynecology
Department of Environmental, Agricultural, and Occupational Health

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Phone: 402-559-5445

Research Overview

The ovary produces the female egg, the oocyte, and hormones which are critical for reproduction and quality-of-life. The effect of a chemical exposure on female reproductive function depends on the developmental/life stage of the exposure as well as the level and duration of exposure. Ovotoxicants can selectively target a follicle population in the ovary, resulting in either temporary or permanent infertility, alter ovarian function maternally, and can also impact offspring through pregestational or in utero exposures. 

While many factors contribute to the global trend in the decline of reproduction rates, the role of environmental exposures in the development of reproductive disorders warrants further investigation. My research program aims to identify the molecular mechanisms responsible for chemical-induced ovarian toxicity, specifically per- and polyfluoroalkyl substances (PFAS). From this, we can provide the means to prevent environmentally induced reproductive failure and preserve fertility. Furthermore, the findings from our research will contribute to the broader understanding of PFAS toxicity, with the overarching goal of informing risk assessment and regulatory strategies to protect public health.

Rasha Ghorab, PhD student presenting her poster at the Greenwald Symposium in Kansas City, Kansas (Fall 2024)