Paul Fey PhD UNMC Department of Pathology Microbiology and Immunology
Dr. Sturd publishes a first author manuscript in mSphere
Chlamydia trachomatis is a leading cause of sexually transmitted infections worldwide. As an obligate intracellular pathogen, it has been selected to establish a niche within the host cell in a membrane-derived vacuole called the chlamydial inclusion. Chlamydial proteins recruit host proteins to the chlamydial inclusion that are critical for infection development. Two of these host-derived […]
Nov 1, 2024
Dr. Angara receives UNMC Office of Post-Doctoral Training’s Excellence in Research Award
Dr. Rajendra Angara discovered a novel Coxiella effector protein, CbEPF1, which is secreted into the host cell cytoplasm and establishes inter-organelle contact sites between the host endoplasmic reticulum (ER) and lipid droplets (LDs). CbEPF1 contains two FFAT motifs, which are typically found in eukaryotic tether proteins that mediate ER-organelle contact sites. Using a combination of microscopy, live cell […]
Nov 1, 2024
Immunoscape
Zachary Van Roy, an MD/PhD trainee in the laboratory of Dr. Tammy Kielian, has indeed had a very productive month as he has published two first author manuscripts in Nature Communication and Cell Reports Medicine. The Cell Reports Medicine manuscript, which he co-first authored with Drs. Gunjan Kak and Lee Korshoj, is the first to […]
Nov 1, 2024
Dr. Abdalla receives Research Scholar Grant from the American Cancer Society
Pancreatic ductal adenocarcinoma (PDAC) is asymptomatic and metastasizes early, leading to a meager 5-year survival rate of ~7%. Chemotherapy has had limited success in extending the life span of patients with advanced PDAC. Dr. Abdalla and his group are extending their expertise in reactive oxygen species by hypothesizing that inhibition of heme oxygenase in combination with […]
Nov 1, 2024
Dr. Fisher receives R37 Merit Award from the National Cancer Institute
Patients with metastatic chemotherapy have a 5 year survival rate of 14% with is exacerbated by K-Ras mutations. Previous work by Dr. Fisher and his team have shown that K-Ras muations increase the transcriptional co-activator PGC-1-b. Thus the goal of this application is to develop novel therapies for metastatic disease that inhibit PGC-1-b. No current, […]
Nov 1, 2024
Apples and Oranges
Zachary Van Roy, an MD/PhD trainee in the laboratory of Dr. Tammy Kielian, has indeed had a very productive month as he has published two first author manuscripts in Nature Communication and Cell Reports Medicine. The manuscript published in Nature Communication established that S. aureus biofilm infections elicit distinct immune and metabolic responses depending on […]
Nov 1, 2024
