Immunomics support for U.S. Army research center
Mariano Sanchez-Lockhart, M.D., pathology & microbiology, has received a task order from the National Strategic Research Institute. Dr. Sanchez-Lockhart will receive more than $1.1million to provide immunomics research support for the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) Center for Genome Sciences.
Clinical studies of novel lymphoma treatments
Julie Vose, M.D., internal medicine – oncology/hematology, has received more than $400,000 in support to conduct two separate clinical trials at UNMC. Dr. Vose is the UNMC lead on a phase 1/2 clinical study that will evaluate the use of a combination monoclonal antibody treatment regimen in patients with relapsed or refractory Hodgkin lymphoma. Dr. Vose is also the UNMC lead on a phase 1/2, multicenter, clinical trial that will assess the safety and efficacy of a novel drug in patients with refractory aggressive non-Hodgkin lymphomas.
Assay development for viral replicon particle formulation
James Talmadge, Ph.D., pathology & microbiology, has received a task order from the National Strategic Research Institute. Dr. Talmadge will receive more than $400,000 to develop assays that will characterize viral replicon particles and their stability under forced degradation to support formulation work.
Development of new Ebola antibody
Steven Hinrichs, M.D., pathology & microbiology, has received more than $200,000 from Emory University to support research into developing a novel antibody for Ebola virus disease.
Mouse model with human immune system for HIV study
Larisa Poluektova, Ph.D., pharmacology & experimental neuroscience, has received a $100,000 award from the National Institute on Drug Abuse. This study will use mouse models with humanized immune systems, developed by Dr. Poluektova’s lab, to monitor HIV reservoirs in the brain under the effects of subtance abuse.
Industry-sponsored grants:
The following industry-sponsored contracts and foundation grants also were received. Information on clinical trials enrolling patients at UNMC can be found here.
Timothy Greiner, M.D., pathology & microbiology, has received support to provide pathology coordination for its Burkitt Lymphoma Genome Sequencing Project through the National Cancer Institute Office of Cancer Genomics.
James Schwarz, M.D., internal medicine – oncology/hematology, is the UNMC lead on a Phase 1b/2 study of a combination therapy for the treatment of metastatic renal cell carcinoma.
Thomas Porter, M.D., internal medicine – cardiology, is the UNMC lead on a prospective, Phase 3 clinical study that will evaluate the use of a new ultrasound contrast agent in CAD patients undergoing pharmacologic stress echocardiography.
Hani Haider, Ph.D., orthopedic surgery, has received support for an in vitro durability study on a novel unicondylar knee system.
Tammy Kielian, Ph.D., pathology & microbiology, has received support from the Batten Disease Support and Research Association to study the synaptic dysfunction in juvenile neuronal ceroid lipofuscinosis.
Surinder Batra, Ph.D., biochemistry & molecular biology, has received support from the University of Nebraska-Lincoln to provide high-specificity micro-RNA microarray analysis as part of cancer screening and research.
Wesley Zeger, D.O., emergency medicine, has received support from the University of Massachusetts-Worcester to be the UNMC site lead in their study to assess the implantation of successful protocols for accurately detecting and effectively managing suicide risk during routine ER visits.
Shane Tsai, M.D., internal medicine – cardiology, has received support to study the outcomes of patients that receive shocks delivered by a subcutaneous implantable defibrillator.
John Colombo, M.D., pediatrics – pulmonology, is the UNMC lead on a Phase 3 clinical study that evaluates the safety and efficacy of a novel combination therapy in patients with cystic fibrosis.
Nora Sarvetnick, Ph.D., surgery – transplant, has received support from the University of Miami to study pancreatic antibacterial responses in type-1 diabetes.
Kari Neemann, M.D., pediatrics – infectious diseases, has received support from the Thrasher Research Fund to study infections of neonates born to pregnant women in Nigeria.
Keely Buesing, M.D., surgery – general surgery, has received support from the University of Nebraska-Lincoln for a study titled "Oxygen Microbubble Peritoneal Ventilation Treatment for Acute Respiratory Distress Syndrome."
Eric Rush, M.D., pediatrics – administration, is the UNMC lead on an expanded access program for asfotase alfa treatment for patients with infantile- or juvenile-onset hypophosphatasia.
Angela Hewlett, M.D., internal medicine – infectious diseases, has received support from the Western University of Health Sciences to evaluate the bacterial burden of polymer nails, nail polish, and natural nails on the hands of health care workers.
Cyrus Desouza, M.B.B.S., internal medicine – diabetes, endocrinology and metabolism, has received technical salary support for his clinical trial sponsored by the Veterans Affairs Nebraska Educational Biomedical Research Association.
Stephen Rennard, M.D., internal medicine – pulmonary, has received support from the University of Pittsburgh to participate in the Network Management Core component of the NIH’s Pulmonary Trials Cooperative, which conducts multiple clinical trials in a variety of chronic pulmonary diseases.
Tony Wilson, Ph.D., pharmacology & experimental neuroscience, has received support from Creighton University for the development of web-based attention training for post traumatic stress disorder (PTSD) studies.
Alexey Kamenskiy, Ph.D., surgery – general surgery, has received support to assess retrievable endovascular arterial markers in a cadaver model of peripheral arterial disease.