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Medical research highlights, April 2025

Mabruka Alfaidi, MD, PhD

The UNMC College of Medicine recently received grants and awards representing nearly $5 million in new funding. Awards included:

  • Benson Edagwa, PhD, pharmacology and experimental neuroscience, received a grant of $978,661 from the DHHS/NIH/NIAID to study dose-flexible, ultra-long-acting prodrug formulations for pediatric populations.
  • Mabruka Alfaidi, MD, PhD, cellular and integrative physiology, received a grant of $410,370 from the DHHS/NIH/NHLBI for a study of IL-1R1 in endothelial-to-mesenchymal activation.
  • Wasim Nasser, PhD, biochemistry and molecular biology, received a grant of $183,220 from U.S. Army/USAMRAA/CDMRP for a study targeting the CCL17/CCR4 axis to eradicate lung cancer brain metastasis.
  • Isuzu Meyer, MD, obstetrics/gynecology, received a grant of $97,567 from Mary Hitchcock Memorial Hospital for a study of reduced dose OnabotulinumtoxinA for urgency urinary incontinence among older women.
  • Rick Starlin, MD, internal medicine-infectious diseases, received a grant of $60,000 from COPD Foundation for the Bronchiectasis and NTM Care Center Network.
  • Cyrus Desouza, MBBS, internal medicine-DEM, received a grant of $42,141 from the Nebraska Educational Biomedical Research Foundation as an ICA for Nate Hudnall.
  • Eleanor Gradidge, MD, pediatrics-critical care, received a grant of $18,618 from Children’s Hospital of Los Angeles for the study “Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome.”
  • Santhi Gorantla, PhD, pharmacology and experimental neuroscience, received a grant of $16,885 from the University of Arizona for a study of ionic liquid-based nanoemulsion containing combination antiretroviral drugs for the oral and transdermal treatment of HIV infection.
  • Jeffrey Salomon, MD, pediatrics-critical care, received a grant of $2,800 from the University of Pennsylvania for the MANTIS study.

Industry-sponsored grants and contracts:

The following industry-sponsored grants and contracts were received.

  • Mridula Krishnan, MBBS, internal medicine-oncology/hematology, received funding for a study of the efficacy of AMG 193 in combination with other therapies in subjects with advanced gastrointestinal, biliary tract or pancreatic cancers with homozygous MTAP-deletion.
  • Apar Ganti, MD, internal medicine-oncology/hematology, received funding for a dose escalation and dose expansion, safety and tolerability study of onCARlytics (CF33-CD19), administered intravenously or intratumorally in combination with Blinatumomab in adults with advanced or metastatic solid tumors.
  • Dr. Edagwa also received funding for development of novel prodrugs of central nervous (CNS) and cardiometabolic medicine, and parenteral injectable formulations.
  • Soonjo Hwang, MD, psychiatry, received funding for a long-term, safety extension study of OLZ/SAM in pediatric subjects with schizophrenia or bipolar I disorder.
  • Ronald Zolty, MD, PhD, internal medicine-cardiovascular, received funding for a study evaluating the long-term safety and efficacy of Seralutinib orally inhaled for the treatment of pulmonary arterial hypertension.
  • Alfred Fisher, MD, PhD, internal medicine-geriatrics, received funding to study a novel platform to facilitate provider adoption of cognitive care planning.
  • Scott Koepsell, MD, PhD, pathology, microbiology and immunology, received funding for validation of the clinical performance of HemosIL CL Anti-Cardiolipin IgG and HemosIL CL Anti-ß2 Glycoprotein-I IgG on the ACL TOP 970 CL Matrix Comparison.
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