Dr. Austin Helmink, chief resident this year, published a first author manuscript entitled “Epithelioid angiosarcoma arising from pleomorphic xanthoastrocytoma, CNS WHO grade 3” in the Journal of Neuropathology & Experimental Neurology.
Post-radiation angiosarcomas are a well-described phenomenon in multiple body sites; however, central nervous system angiosarcomas are extremely rare and their molecular tumorigenesis is unclear. In this paper, the investigative team reported the first case of post-radiation angiosarcomatous transformation from a pleomorphic xanthoastrocytoma and also discuss the possible pathogenetic mechanisms which could hopefully lead to future development of targeted therapies. Drs. Sahara Cathcart, Zhenya Tang, Dominick DiMaio, Samir Atiya, and Jie Chen were among the co-authors on this manuscript.