Luke Hamilton, a graduate research assistant in the UNMC Department of Anesthesiology and PhD student in neuroscience, recently was awarded a fellowship from the Neuroimmunology of Disease Training Program. The fellowship offers opportunities to conduct neuroscience/neuroimmunology related research, clinical shadowing in neurology and rigorous training in statistical methodologies. For Hamilton, the program aligns seamlessly with his dissertation work and career aspirations.
With roots in Bridgeport, Nebraska, and a lifelong fascination with biology, Hamilton’s academic journey reflects his evolving passion for the sciences, particularly the field of neuroimmunology.
Hamilton’s love for biology began in elementary school with a childhood dream of becoming an ornithologist. By high school, and after shadowing local doctors, his interests had shifted toward health sciences. “I fell in love with the brain in college,” Hamilton said. His academic pursuits became increasingly focused on neuroscience, driven by personal experiences with mental health and a fascination with the human brain.
Hamilton completed both his bachelor’s and master’s degrees in biology at the University of Nebraska at Kearney, followed by a year as a research technician. His decision to pursue a PhD at UNMC was motivated by a strong support network in Nebraska and his growing interest in neuroimmunology.
Hamilton’s dissertation investigates the effects of in utero exposure to oxycodone and social stress during adolescence on brain development, specifically through the lens of neuroinflammation. Guided by his adviser, Sowmya Yelamanchili, PhD, Hamilton is investigating how these dual stressors influence neurodevelopment, a topic with significant implications for understanding mental health disorders and brain function.
“This fellowship has allowed me to delve deeper into the relationship between the nervous and immune systems,” Hamilton said. “We’re just beginning to understand how these systems interact, especially in the context of stress and neurodegeneration.”
Dr. Yelemanchili said she is thankful to the IGPBS-Neuroscience program and its director, Daniel Monaghan, PhD, to have selected Hamilton as an awardee this year. “This is particularly rewarding to him as he intends to pursue a non-conventional path to become a clinician scientist. I wish him the best in his journey.”
While Hamilton’s path might seem unconventional, with a PhD preceding medical school, his trajectory is intentional. He aspires to become an academic child and adolescent psychiatrist, blending clinical practice with research and education. “The PhD provides a deeper understanding of the brain and equips me with the skills to teach and conduct research,” he said.
Hamilton also champions the idea of broadening career paths for PhD students in the health sciences, saying: “PhD students in departments like anesthesiology often feel limited to academia or industry, but clinical paths should be more normalized.”
With the NIH fellowship supporting his current research and advancing his long-term goals, Hamilton’s work exemplifies the potential of interdisciplinary training to advance both scientific discovery and clinical practice.
“I hope to inspire others to consider diverse paths in health sciences,” Hamilton said. “We need to keep opening doors—for ourselves and the next generation of researchers and clinicians.”