Medical research highlights, Summer 2024

Vimla Band, PhD

The UNMC College of Medicine received grant and funding awards representing more than $4 million in new funding in April and May. Awards included:

Vimla Band, PhD, genetics, cell biology and anatomy, received a grant of $1,544,999 from the U.S. Army/USAMRAA/CDMRP for the study “A Novel ER Stress Mitigation Pathway in ErbB2-Driven Oncogenesis.”

Aditya Bade, PhD, pharmacology and experimental neuroscience, received a grant of $573,445 from the DHHS/NHI/Office of the Director for the study “Integrase Inhibitors during Pregnancy and Neurodevelopmental Outcomes: Underlying Mechanism and Therapeutic Intervention.”

Padmashri Ragunathan, PhD, neurological sciences, received a grant of $343,931 from the DHS/NHI/NIAA for the study “Cellular mechanisms of auditory processing deficits in a mouse model of fetal alcohol spectrum disorders.”

Joseph Americo Fernandes, MD, neurological sciences, received a grant of $250,000 from Massachusetts General Hospital for a master agreement on the ALL ALS East – ALL ALS Consortium project.

Justin Mott, MD, PhD, biochemistry and molecular biology, received a grant of $125,935 from DHHS/NIH/NIGMS for the medical scientist training program at the University of Nebraska.

Matthew Zimmerman, PhD, cellular and integrative physiology, received a grant of $102,645 from Boys Town National Research Hospital for the study “Coupling of Elevated Inflammasome Levels and Altered Neural Oscillatory Dynamics in NeuroHIV.”

Aaron Barksdale, MD, emergency medicine, received a grant of $42,001 from the University of Michigan for “POST-ICECAP (Patterns Of Survivors’ recovery Trajectories in the ICECAP trial).”

Jordan Rowley, PhD, genetics, cell biology and anatomy, received a grant of $38,934 from Fordham University for a study on “Decoding the X-Chromosome Dynamics in the Adult Female Brain.”

Abi Heller, neurological sciences, received a grant of $37,727 from DHS/NIH/NIA for a study measuring neurodevelopmental effects of genetic risk for Alzheimer’s disease via cross-sectional study of brain, cognitive, and physical fitness variables in periadolescent children.

Jill Beck, MD, pediatrics-hematology/oncology, received grants of $15,253 and $4,320 from Children’s Nebraska as COG CHMC subawards.

Karsten Bartels, MD, PhD, anesthesiology, received a grant of $6,300 from the Foundation for Anesthesia Education and Research for MSARF Summer 2024.

Kari Neeman, MD, pediatrics-infectious diseases, received a grant of $6,000 from the Arkansas Children’s Hospital Research Institute for “Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients.”

Tammy Wichman, MD, internal medicine-pulmonary, received a grant of $5,250 from the University of Pennsylvania for the study “Physical Activity in Pulmonary Arterial Hypertension.”

Industry-sponsored grants and contracts:

The following industry-sponsored grants and contracts were received.

Marian Urban, MD, PhD, surgery-cardiothoracic surgery, received funding for a study of hearts transplanted after non-ischemic heart preservation from extended donors.

Kelsey Klute, MD, internal medicine-oncology/hematology, received funding for “TIGeR-PaC: Targeted Intra-arterial Gemcitabine vs. Continuation of IV Gemcitabine plus Nab-Paclitaxel following Induction with sequential IV Gemcitabine plus Nab-Paclitaxel and Radiotherapy for Unresectable Locally Advanced Pancreatic Cancer.”

Vijaya Bhatt, MBBS, internal medicine-oncology/hematology, received funding for a study to investigate the efficacy and safety of CYP-001 in combination with corticosteroids vs. corticosteroids alone.”

Omar Abughanimeh, MBBS, internal medicine-oncology/hematology, received funding for two studies: a study of Brentuximab Vedotin in combination with pembrolizumab in subjects with metastatic solid malignancies; and a study of HLX10 plus chemotherapy (Carboplatin-Etoposide) in comparison with Atezolizumab plus chemotherapy in previously untreated U.S. patients with extensive stage small Cell lung cancer.

Kerry Rodabaugh, MD, obstetrics and gynecology, received funding as a member institution clinical trial fixed price sub-award agreement.

Chittalsinh Raulji, MBBS, pediatrics-hematology/oncology, received funding for the Concizumab compassionate use program for patients with congenital hemophilia.

Ronald Zolty, MD, PhD, internal medicine-cardiovascular, received funding for a study of Levosimendan in pulmonary hypertension patients with heart failure and preserved left ventricular ejection fraction.

Samia Asif, MBBS, internal medicine-oncology/hematology, received funding for a study of Ribociclib vs. Palbociclib in patients with advanced hormone receptor-positive/HER2-negative/HER2-enriched breast cancer.

Cyrus Desouza, MBBS, internal medicine-DEM, received funding for a study to evaluate the efficacy and safety of once-weekly insulin Icodec when switching from daily basal insulins compared to once-daily insulin Glargine U100 in adults with type 2 diabetes; and a study of the efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema 2.4mg/2.4 mg) once weekly versus semaglutide 2.4 mg, cagrilintide 2.4 mg and placebo in people with chronic kidney disease and type 2 diabetes.

William Rizzo, MD, pediatrics-metabolism, received funding for a post-trial access program: “Idursulfase-IT (HGT-2310) in Conjunction with Intravenous Elaprase in Pediatric Patients with Hunter Syndrome and Cognitive Impairment.”