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Medical research highlights, May 2024

Sudjata Chaudhari, PhD

The UNMC College of Medicine received grant and funding awards representing nearly $3 million in new funding in March. Awards included:

Sujata Chaudhari, PhD, pathology, microbiology and immunology, received a grant of $1,229,964 from NSF for the study “Understanding the Molecular Mechanisms of Insect Cuticular Chitin Maintenance.”

Sunyoung Kim, PhD, surgery-cardiothoracic surgery, received a grant of $143,764 from the American Heart Association for the study “Alcohol and Notch Pathway Mutations Synergistically Induce Atrioventricular Canal Defects: Potential Rescue by Folate.”

Iraklis Pipinos, MD, surgery-vascular surgery, received a grant of $131,384 from the University of Nebraska at Omaha for the Center for Cardiovascular Research in Biomechanics.

Austin Wheeler, MD, internal medicine-rheumatology, received a grant of $125,000 from the Rheumatology Research Foundation for work on the development of a comprehensive risk score for rheumatoid arthritis-associated interstitial lung disease and progression.

Seema Singh, PhD, pharmacology and experimental neuroscience, received a grant of $76,750 from DHHS/NIH/NIAA for the study “HIV Tat and alcohol-mediated activation of astrocytes involves ER stress/NLRP6 inflammasome axis.”

Steve Gliske, PhD, neurosurgery, received a grant of $412,862 from the University of Michigan for a study characterizing High-frequency oscillations as an epilepsy biomarker with big data tools.

Shibiao Wan, PhD, genetics, cell biology and anatomy, received a grant of $25,000 from Nebraska EPSCoR for “A Unified Machine Learning Framework to Integrate Large-Scale Single Cell and Bulk Multi-Omics Data for Cancer Subtyping.”

Bryant England, MD, PhD, internal medicine-rheumatology, received a grant of $16,380 from the University of Pennsylvania School of Medicine for a study of genetic predictors of metabolic adverse effects with glucocorticoid treatment in patients with rheumatoid arthritis.

Scott Lundgren, DO, internal medicine-cardiovascular, received a grant of $16,000 from Tufts Medical Center for the Pulmonary Artery Catheter in Cardiogenic Shock Trial.

Prasanth Ravipati, MD, internal medicine-nephrology, received a grant of $1,000 from Benaroya Research Institute at Virginia Mason for a study on the efficacy of Belimumab and Rituximab compared to Rituximab alone for the treatment of primary membranous nephropathy.

Industry-sponsored grants and contracts:

The following industry-sponsored grants and contracts were received.

Cyrus Desouza, MBBS, internal medicine-DEM, received funding for a study to evaluate the effect of inclisiran on preventing major adverse cardiovascular events in high-risk primary prevention patients.

Scott Westphal, MD, internal medicine-nephrology, received funding for a study evaluating the safety and efficacy of Tegoprubart in patients undergoing kKidney transplantation.

Pukhraj Rishi, MBBS, ophthalmology and visual sciences, received funding for a trial to evaluate efficacy and safety of belzupacap sarotalocan (AU-011) treatment compared to sham control in subjects with primary indeterminate lesions or small choroidal melanoma.

Soonjo Hwang, MD, psychiatry, received funding for a study of OLZ/SAM vs. Olanzapine to evaluate weight gain as assessed by change in BMI Z-score in pediatric subjects with schizophrenia or bipolar I disorder.

Erin Barrett, MD, dermatology, received funding for a study of patients receiving Dupilumab for prurigo nodularis.

Carlos Gomez, MD, internal medicine-infectious diseases, received funding to evaluate the efficacy and safety of CAL02 administered intravenously in addition to standard of care in subjects with severe community-acquired bacterial pneumonia.

Scott Koepsell, MD, PhD, pathology/microbiology, received funding for a study of HemosIL CL HIT-IgG(PF4-H) reagents on the ACL TOP 970 CL instrument.

Christopher D’Angelo, MD, internal medicine-oncology/hematology, received funding for an intermediate-size population expanded access program for cilta-cel out-of specification (OOS) in patients with multiple myeloma.

Hani Haider, PhD, orthopedic surgery, received funding for a work order: Dynamic post fatigue testing of the Optimotion PS Total Knee Replacement System.