Department Profile – Radiation Oncology

Department:  Radiation Oncology

Chair:  Charles Enke, M.D.

No. of people in department (faculty/staff):  69 total individuals working in radiation oncology

Nebraska Medicine-affiliated employees: 40

UNMC-affiliated employees: 29

Faculty:  16

Staff:  7

Resident physicians and physicist: 6

New faculty:

Chi (Kevin) Zhang, MD, Ph.D., radiation oncologist, translational research

Ying Yang, Ph.D., cancer cell biologist, radiation & chemotherapy research

Qiyong Fan, Ph.D., medical physicist

Xiaofeng (Drew) Zhu, Ph.D., medical physics research

Xin Wang, Ph.D., medical physicist

Educational programs:

Medical residency program started July 1, 2010

Medical physics residency program started July 1, 2001

Affiliation with the College of Allied Health Professions/Radiation Science Technology Education (RSTE) Program

Significant research grants/publications:

There were more than 108 publications in peer reviewed journals by department faculty from Jan. 1, 2013 through Dec. 31, 2015. 

Here is the reference for one of the more prominent publications:

Kortylewicz ZP, Mack E, Enke C.A, Estes KA, Mosley RL, Baranowska-Kortylewicz J. Preclinical evaluation of investigational radiopharmaceutical RISAD-P intended for use as a diagnostic and molecular radiotherapy agent for prostate cancer. Prostate. 2015 Jan;75(1):8-22. doi: 10.1002/pros.22885. Epub 2014 Oct 4. PMID: 25283970.

Grant:

Department faculty have been involved in several grants including:

Ying Yan, Ph.D

Title: Rac1 GTPase in tumorigenesis and progression of pancreatic cancer (NCI / R01 CA206444-01)

Finding Source: NIH-R01/NCI

Principal Investigators: Michel M. Ouellette and Surinder Batra (Multiple PI)

Role in Project: Co-investigator

Percent Effort: 5 percent

Dates:   04/01/2016 to 03/31/2021

Total Direct Cost: $1.5 million

Status: 4th percentile in TCB study section

Goal of this project is to define the role of RAC1 GTPase in pancreatic cancer development.

Other highlights:

Clinical locations:

  1. Nebraska Medical Center, Clarkson Tower
  2. Village Pointe Cancer Center
  3. Nebraska Medicine Radiation Oncology at Shenandoah Memorial Hospital, Shenandoah, Iowa.

New Technology:

  1. Varian TrueBeam STx- Treatment system for cranial stereotactic radiosurgery (SRS) and stereotactic body radiosurgery (SABR). 
  2. Varian kV Cone Beam CT based IGRT
  3. Varian Eclipse Treatment Planning System
  4. Varian Respiratory Motion Management System

New/Expanded Clinical Programs:

  • Prone positioning for breast radiation therapy
  • Stereotactic body radiosurgery (SABR 4 or 5 high dose radiation fractions) for lung cancer, pancreatic cancer, hepatocellular carcinoma. 
  • Single fraction of 8 gray treatment for osseous metastasis. 
  • High dose rate (HDR) brachytherapy for partial breast irradiation, gynecologic cancers and intra-operative radiation therapy. 
  • "Boom-Boom" 2 gray per fraction times 2 fractions for palliation of low grade lymphomas. 
  • Frameless single fraction stereotactic radiosurgery for simultaneous treatment of up to 3 brain metastasis.

 

Oi CrL WdrTO