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University of Nebraska Medical Center

Category: Published Research

SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model

Science Some people infected with SARS-CoV-2, the virus that causes COVID-19, experience a range of symptoms after the resolution of infection, such as neurological issues that include generalized pain, neuropathy, and myalgia. Serafini et al. found that non-infectious viral RNA was detectable in the dorsal root ganglia of hamsters after intranasal infection with SARS-CoV-2. This phenomenon […]

May 9, 2023

COVID’s future: mini-waves rather than seasonal surges

Nature Whether you call it a surge, a spike, a wave or perhaps just a wavelet, there are signs of a rise in SARS-CoV-2 infections — again. A growing proportion of tests in some countries are coming back positive, and new variants, most notably a lineage called XBB.1.16, are pushing aside older strains, fuelling some […]

May 2, 2023

Clinical improvement of Long-COVID is associated with reduction in autoantibodies, lipids, and inflammation following therapeutic apheresis

Nature In the aftermath of the COVID-19 pandemic, we are witnessing an unprecedented wave of post-infectious complications. Most prominently, millions of patients with Long-Covid complain about chronic fatigue and severe post-exertional malaise. Therapeutic apheresis has been suggested as an efficient treatment option for alleviating and mitigating symptoms in this desperate group of patients. However, little […]

May 2, 2023

SARS-CoV-2 awakens ancient retroviral genes and the expression of proinflammatory HERV-W envelope protein in COVID-19 patients

PubMed atients with COVID-19 may develop abnormal inflammatory response, followed in some cases by severe disease and long-lasting syndromes. We show here that in vitro exposure to SARS-CoV-2 activates the expression of the human endogenous retrovirus (HERV) HERV-W proinflammatory envelope protein (ENV) in peripheral blood mononuclear cells from a subset of healthy donors, in ACE2 receptor and […]

Apr 25, 2023

SARS-CoV-2 incubation period across variants of concern, individual factors, and circumstances of infection in France: a case series analysis from the ComCor study

The Lancet/Microbe The incubation period of SARS-CoV-2 has been estimated for the known variants of concern. However, differences in study designs and settings make comparing variants difficult. We aimed to estimate the incubation period for each variant of concern compared with the historical strain within a unique and large study to identify individual factors and […]

Apr 18, 2023

Aberrant olfactory network functional connectivity in people with olfactory dysfunction following COVID-19 infection: an exploratory, observational study

The Lancet Olfactory impairments and anosmia from COVID-19 infection typically resolve within 2–4 weeks, although in some cases, symptoms persist longer. COVID-19-related anosmia is associated with olfactory bulb atrophy, however, the impact on cortical structures is relatively unknown, particularly in those with long-term symptoms.

Apr 18, 2023

Obesity and COVID-19 mortality are correlated

Nature Abstract In view of a conspicuous absence of any cross-country study linking obesity and COVID-19 mortality, we conduct an empirical analysis of plausible associations between COVID-19 mortality and the proportion of obese in the adult population distributed across 142 countries around the globe. We observe a statistically significant positive association between COVID-19 mortality and […]

Apr 11, 2023

Computed Tomography Imaging for Monitoring of Marburg Virus Disease: a Nonhuman Primate Proof-Of-Concept Study

ASM ABSTRACT Marburg virus (MARV) is a highly virulent zoonotic filovirid that causes Marburg virus disease (MVD) in humans. The pathogenesis of MVD remains poorly understood, partially due to the low number of cases that can be studied, the absence of state-of-the-art medical equipment in areas where cases are reported, and limitations on the number […]

Apr 11, 2023

Risk factors and vectors for SARS-CoV-2 household transmission: a prospective, longitudinal cohort study

The Lancet Summary Despite circumstantial evidence for aerosol and fomite spread of SARS-CoV-2, empirical data linking either pathway with transmission are scarce. Here we aimed to assess whether the presence of SARS-CoV-2 on frequently-touched surfaces and residents’ hands was a predictor of SARS-CoV-2 household transmission. Methods In this longitudinal cohort study, during the pre-alpha (September […]

Apr 11, 2023

Severe Maternal Morbidity and Mortality of Pregnant Patients With COVID-19 Infection During the Early Pandemic Period in the US

JAMA From the beginning of the COVID-19 pandemic in mid-March, 2020, through mid-February 2023, nearly 103 million cases and 1.1 million deaths were reported in the United States.1 Increasing evidence suggests that pregnant patients with COVID-19 infection are at high risk for adverse pregnancy outcomes.2–4 Several studies have examined outcomes before and during the pandemic periods.2–4 National-level […]

Apr 11, 2023