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University of Nebraska Medical Center

Category: Published Research

Lingering cardiac involvement in previously well people after mild COVID-19

Nature Medicine – Lingering cardiac symptoms, including exercise intolerance, tachycardia and chest pain, are increasingly recognized as post-acute COVID-19 sequelae1. In patients with a severe course of initial illness, accrued cardiac injury and pre-existing conditions readily explain cardiac symptoms. However, signs of cardiac injury such as elevated troponin levels and structural heart disease are rare […]

Sep 26, 2022

Clinical studies of detecting COVID-19 from exhaled breath with electronic nose

Nature – The COVID-19 pandemic has attracted numerous research studies because of its impact on society and the economy. The pandemic has led to progress in the development of diagnostic methods, utilizing the polymerase chain reaction (PCR) as the gold standard for coronavirus SARS-CoV-2 detection. Numerous tests can be used at home within 15 min or […]

Sep 26, 2022

Monkeypox in a Young Infant

CDC – In August 2022, the Florida Department of Health (FDOH) was notified of a suspected case of monkeypox in an infant aged <2 months who was admitted to a Florida hospital with a rash and cellulitis. This case report highlights findings from the related epidemiologic investigation and describes the public health actions taken. This […]

Sep 26, 2022

Neurologic Complications of Smallpox and Monkeypox

JAMA Neurology – Orthopox viruses include smallpox virus, a once feared but now eradicated virus, as well as monkeypox virus. Monkeypox is an emerging virus initially isolated in 1958, previously unrecognized outside sub-Saharan Africa until a worldwide outbreak in May 2022. It is important to review known neurologic consequences of both these viruses, as complications […]

Sep 26, 2022

SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages

Science – Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the underlying mechanism is unknown. To explore whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of adipose tissue contributes to pathogenesis, we evaluated COVID-19 autopsy cases and deeply profiled the response of […]

Sep 25, 2022

SARS-CoV-2 Omicron and its current known unknowns: A narrative review

Pub Med – The emergence of the SARS-CoV-2 Omicron variant (B.1.1.529) has created great global distress. This variant of concern shows multiple sublineages, importantly B.1.1.529.1 (BA.1), BA.1 + R346K (BA.1.1), and B.1.1.529.2 (BA.2), each with unique properties. However, little is known about this new variant, specifically its sub-variants. A narrative review was conducted to summarise […]

Sep 24, 2022

Mixing patterns and the spread of pandemics

Nature – Integrating social mixing data into epidemic models can help policy makers better understand epidemic spread. However, empirical mixing data might not be immediately available in most populations. In a recent work, a network model methodology is proposed to construct micro-level social mixing structure when empirical data are not available.

Sep 23, 2022

Reinfections with Different SARS-CoV-2 Omicron Subvariants, France

CDC – We describe 188 patients in France who were successively infected with different SARS-CoV-2 Omicron subvariants, including BA.1, BA.2, and BA.5. Time between 2 infections was <90 days for 50 (26.6%) patients and <60 days for 28 (14.9%) patients. This finding suggests that definitions for SARS-CoV-2 reinfection require revision.

Sep 23, 2022

Pulmonary Dysfunction after Pediatric COVID-19

Radiology – Long COVID occurs in lower frequency in children and adolescents than in adults. Morphologic and free-breathing phase-resolved functional low-field MRI may identify persistent pulmonary manifestations after SARS-CoV-2 infection.

Sep 23, 2022

Circulating anti-nuclear autoantibodies in COVID-19 survivors predict long-COVID symptoms

European Respiratory Journal – Autoimmunity has been reported in patients with severe COVID-19. We investigated whether antinuclear/extractable-nuclear antibodies (ANAs) were present up to a year after infection, and if they were associated with the development of clinically relevant Post-Acute Sequalae of COVID-19 (PASC) symptoms.

Sep 23, 2022