Category: Published Research
Remdesivir resistance in transplant recipients with persistent COVID-19
Clinical Infectious Diseases – New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications. Download […]
Sep 28, 2022
CDC – Increases in severe respiratory illness and acute flaccid myelitis (AFM) among children and adolescents resulting from enterovirus D68 (EV-D68) infections occurred biennially in the United States during 2014, 2016, and 2018, primarily in late summer and fall. Although EV-D68 annual trends are not fully understood, EV-D68 levels were lower than expected in 2020, […]
Sep 28, 2022
Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants
The Lancet – SARS-CoV-2 BA.4 and BA.5 lineages have been the dominant strains in most regions worldwide and are continuously gaining mutations in the receptor-binding domain. Multiple BA.4 and BA.5 subvariants with Arg346 mutations in the spike glycoprotein have been identified in various countries, such as BA.4.6, BF.7, BA.5.2.6, BA.4.1.9, and BE.1.2 harbouring Arg346Thr; BA.4.7 […]
Sep 28, 2022
Host and viral proteins involved in SARS-CoV-2 infection differentially bind heme
PubMed – In most severe cases, SARS-CoV-2-induced autoimmune reactions have been associated with hemolytic complications. Hemolysis-derived heme from ruptured red blood cells has been shown to trigger a variety of fatal proinflammatory and procoagulant effects, which might deteriorate the progression of COVID-19. In addition, the virus itself can induce proinflammatory signals via the accessory protein […]
Sep 28, 2022
Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses
Nature – Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus Betacoronavirus. The ancestor strain has evolved into a number of variants of concern, with the Omicron variant of concern now having many distinct sublineages. The ongoing COVID-19 pandemic caused by […]
Sep 28, 2022
A practical update on the management of patients with COVID–19
Royal College of Physicians – While vaccines against COVID-19 are being rolled out, an ongoing need remains for therapies to treat patients who have symptomatic COVID-19 before vaccination or in whom breakthrough infection develops. Dexamethasone and interleukin-6 inhibitors have been the mainstay of treatment for severe to critical COVID-19 requiring hospitalisation. However, in the previous […]
Sep 27, 2022
Hybrid immunity and strategies for COVID-19 vaccination
The Lancet Infectious Diseases – Since April, 2022, BA.2.12.1, BA.4, and BA.5 subvariants of the omicron (B.1.1.529) SARS-CoV-2 variant of concern have been spreading globally with increased viral fitness and transmissibility. Omicron BA.5 subvariant is currently the predominant COVID-19 threat worldwide. With the emergence of the antigenically distinct variants of concern, either natural immunity or […]
Sep 27, 2022
Journal of Clinical Virology – The factors contributing to delayed viral clearance in COVID-19 are still unclear.•The authors investigated these factors in a study of a multiethnic population.• Advanced age, cardiovascular comorbidity, and severe COVID-19 all led to Delayed viral clearance• This early recognition enables for a detailed strategy to optimize the outcome.
Sep 27, 2022
Test predicts which COVID-19 patients will grow worse, Stanford Medicine study find
Stanford Medicine – Elevated virus levels in hospitalized COVID-19 patients’ blood predicts worsening respiratory symptoms and suggests ongoing viral replication in later disease stages, Stanford Medicine-led study says. A one-time test could predict which people hospitalized with COVID-19 are likely to worsen significantly during their stay, even if they were admitted with relatively mild symptoms, […]
Sep 26, 2022
Frontiers in Microbiology – Pilitropic and flagellotropic phages adsorb to bacterial pili and flagella. These phages have long been used to investigate multiple aspects of bacterial physiology, such as the cell cycle control in the Caulobacterales. Targeting cellular appendages for adsorption effectively constrains the population of infectable hosts, suggesting that phages may have developed strategies […]
Sep 26, 2022