Category: Published Research
Recurrence of Symptoms Following a 2-Day Symptom Free Period in Patients With COVID-19
(JAMA) Recurrence of symptoms after finishing treatment for COVID-19 with nirmatrelvir-ritonavir (Paxlovid) has become increasingly recognized.1–3 The biological underpinning of this phenomenon is unclear, and its etiology may be multifactorial, including rapid clearance of nirmatrelvir coupled with delayed immune responses or possible development of drug resistance.1–3 The contribution of treatment to symptom rebound needs to be differentiated […]
Oct 28, 2022
Cardiovascular disease and mortality sequelae of COVID-19 in the UK Biobank
(BMJ) Objective To examine association of COVID-19 with incident cardiovascular events in 17 871 UK Biobank cases between March 2020 and 2021. Methods COVID-19 cases were defined using health record linkage. Each case was propensity score-matched to two uninfected controls on age, sex, deprivation, body mass index, ethnicity, diabetes, prevalent ischaemic heart disease (IHD), smoking, hypertension and high […]
Oct 25, 2022
During the first year of the pandemic, men died from COVID at a much higher rate than women
(CDC) Death rates in the United States are higher in rural than urban areas, andthe difference has grown over the last 2 decades (1). Death rates for all ofthe 10 leading causes of death in 2019 were higher in rural than urban areas(1). In 2020, deaths due to COVID-19 became the third leading cause ofdeath […]
Oct 25, 2022
(Nature) The immune-inflammatory response during the acute phase of COVID-19, as assessed using peak body temperature (PBT) and peripheral oxygen saturation (SpO2), predicts the severity of chronic fatigue, depression and anxiety symptoms 3–4 months later.
Oct 24, 2022
(Nature) The purposes of our study are to map high-risk areas in Canada as well as quantifying the effects of vaccination intervention and socio-demographic factors on the transmission rates of infection, recovery, and death related to COVID-19. The data of this research included weekly number of COVID‑19 cases, recovered, and dead individuals from 2020 through […]
Oct 24, 2022
(The Lancet) Estimates of immunity and severity for the SARS-CoV-2 omicron subvariant BA.5 are important to assess the public health impact associated with its rapid global spread despite vaccination. We estimated natural and vaccine immunity and severity of BA.5 relative to BA.2 in Denmark, a country with high mRNA-vaccination coverage and free-of-charge RT-PCR testing.
Oct 18, 2022
Monkeypox after Occupational Needlestick Injury from Pustule
CDC EID – We report a case of monkeypox in a physician after an occupational needlestick injury from a pustule. This case highlights risk for occupational transmission and manifestations of the disease after percutaneous transmission: a short incubation period, followed by a solitary lesion at the injured site and later by systemic symptoms.
Oct 18, 2022
Outcomes among confirmed cases and a matched comparison group in the Long-COVID in Scotland study
Nature – With increasing numbers infected by SARS-CoV-2, understanding long-COVID is essential to inform health and social care support. A Scottish population cohort of 33,281 laboratory-confirmed SARS-CoV-2 infections and 62,957 never-infected individuals were followed-up via 6, 12 and 18-month questionnaires and linkage to hospitalization and death records. Of the 31,486 symptomatic infections,1,856 (6%) had not […]
Oct 13, 2022
SARS-CoV-2 variants of concern and
variants under investigation in England
UK Health Security Agency – This report has been published to share the detailed variant surveillance analyses whichcontribute to the variant risk assessments and designation of new SARS-CoV-2 variants.This specialist technical briefing contains early data and analysis on emerging variants andfindings have a high level of uncertainty. Unless stated otherwise, this technical briefing uses a […]
Oct 13, 2022
Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults
JAMA – In this systematic review and meta-analysis of 38 studies comprising 2160 participants, exercise capacity was reduced by 4.9 mL/kg/min among individuals with symptoms consistent with LC compared with individuals without symptoms more than 3 months after SARS-CoV-2 infection. Findings among individuals with exertional intolerance suggest that deconditioning, dysfunctional breathing, chronotropic incompetence, and abnormal […]
Oct 13, 2022