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University of Nebraska Medical Center

Category: Published Research

During the first year of the pandemic, men died from COVID at a much higher rate than women

(CDC) Death rates in the United States are higher in rural than urban areas, andthe difference has grown over the last 2 decades (1). Death rates for all ofthe 10 leading causes of death in 2019 were higher in rural than urban areas(1). In 2020, deaths due to COVID-19 became the third leading cause ofdeath […]

Oct 25, 2022

Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study

(Nature) The immune-inflammatory response during the acute phase of COVID-19, as assessed using peak body temperature (PBT) and peripheral oxygen saturation (SpO2), predicts the severity of chronic fatigue, depression and anxiety symptoms 3–4 months later.

Oct 24, 2022

Modeling the spatio‑temporal spread of COVID‑19 cases, recoveries and deaths and effects of partial and full vaccination coverage in Canada

(Nature) The purposes of our study are to map high-risk areas in Canada as well as quantifying the effects of vaccination intervention and socio-demographic factors on the transmission rates of infection, recovery, and death related to COVID-19. The data of this research included weekly number of COVID‑19 cases, recovered, and dead individuals from 2020 through […]

Oct 24, 2022

Risk of reinfection, vaccine protection, and severity of infection with the BA.5 omicron subvariant: a nation-wide population-based study in Denmark

(The Lancet) Estimates of immunity and severity for the SARS-CoV-2 omicron subvariant BA.5 are important to assess the public health impact associated with its rapid global spread despite vaccination. We estimated natural and vaccine immunity and severity of BA.5 relative to BA.2 in Denmark, a country with high mRNA-vaccination coverage and free-of-charge RT-PCR testing.

Oct 18, 2022

Monkeypox after Occupational Needlestick Injury from Pustule

CDC EID – We report a case of monkeypox in a physician after an occupational needlestick injury from a pustule. This case highlights risk for occupational transmission and manifestations of the disease after percutaneous transmission: a short incubation period, followed by a solitary lesion at the injured site and later by systemic symptoms.

Oct 18, 2022

Outcomes among confirmed cases and a matched comparison group in the Long-COVID in Scotland study

Nature – With increasing numbers infected by SARS-CoV-2, understanding long-COVID is essential to inform health and social care support. A Scottish population cohort of 33,281 laboratory-confirmed SARS-CoV-2 infections and 62,957 never-infected individuals were followed-up via 6, 12 and 18-month questionnaires and linkage to hospitalization and death records. Of the 31,486 symptomatic infections,1,856 (6%) had not […]

Oct 13, 2022

SARS-CoV-2 variants of concern and
variants under investigation in England

UK Health Security Agency – This report has been published to share the detailed variant surveillance analyses whichcontribute to the variant risk assessments and designation of new SARS-CoV-2 variants.This specialist technical briefing contains early data and analysis on emerging variants andfindings have a high level of uncertainty. Unless stated otherwise, this technical briefing uses a […]

Oct 13, 2022

Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults

JAMA – In this systematic review and meta-analysis of 38 studies comprising 2160 participants, exercise capacity was reduced by 4.9 mL/kg/min among individuals with symptoms consistent with LC compared with individuals without symptoms more than 3 months after SARS-CoV-2 infection. Findings among individuals with exertional intolerance suggest that deconditioning, dysfunctional breathing, chronotropic incompetence, and abnormal […]

Oct 13, 2022

Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021

JAMA – This observational analysis involved bayesian meta-regression and pooling of 54 studies and 2 medical record databases with data for 1.2 million individuals (from 22 countries) who had symptomatic SARS-CoV-2 infection. The modeled estimated proportion with at least 1 of the 3 self-reported Long COVID symptom clusters 3 months after symptomatic SARS-CoV-2 infection was […]

Oct 11, 2022

Differential personality change earlier and later in the coronavirus pandemic in a longitudinal sample of adults in the United States

PLoS – Five-factor model personality traits (neuroticism, extraversion, openness, agreeableness, conscientiousness) are thought to be relatively impervious to environmental demands in adulthood. The coronavirus pandemic is an unprecedented opportunity to examine whether personality changed during a stressful global event. Surprisingly, two previous studies found that neuroticism decreased early in the pandemic, whereas there was less […]

Oct 5, 2022