Category: Published Research
Severe COVID-19 is associated with molecular signatures of aging in the human brain
(Nature Aging) As coronavirus disease 2019 (COVID-19) and aging are both accompanied by cognitive decline, we hypothesized that COVID-19 might lead to molecular signatures similar to aging. We performed whole-transcriptome analysis of the frontal cortex, a critical area for cognitive function, in individuals with COVID-19, age-matched and sex-matched uninfected controls, and uninfected individuals with intensive […]
Dec 12, 2022
The negative impact of COVID-19 on working memory revealed using a rapid online quiz
(PLoS) Although coronavirus disease 2019 (COVID-19) affects the respiratory system, it can also have neurological consequences leading to cognitive deficits such as memory problems. The aim of our study was to assess the impact of COVID-19 on working memory function. We developed and implemented an online anonymous survey with a working memory quiz incorporating aspects […]
Dec 6, 2022
(American Journal of Respiratory and Critical Care Medicine) Rationale. Shared symptoms and genetic architecture between COVID-19 and lungfibrosis suggests SARS-CoV-2 infection may lead to progressive lung damage.Objectives. The UKILD Post-COVID study interim analysis was planned to estimate theprevalence of residual lung abnormalities in people hospitalized with COVID-19 based onrisk strata. Methods. The Post-HOSPitalisation COVID Study […]
Dec 5, 2022
Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers
(Annals of Internal Medicine) Background: It is uncertain if medical masks offer similar protection against COVID-19 compared with N95 respirators. Objective: To determine whether medical masks are noninferior to N95 respirators to prevent COVID-19 in health care workers providing routine care. Design: Multicenter, randomized, noninferiority trial. (ClinicalTrials.gov: NCT04296643).
Nov 29, 2022
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
(Science) Because we cannot currently predict which subtype of the influenza virus will cause the next pandemic, researchers have made various attempts to produce a “universal” vaccine that could protect people from a wide swathe of subtypes. Although most of these efforts have focused on a limited set of antigens that are shared by many […]
Nov 29, 2022
(PLoS) Superspreading events are important drivers of the SARS-CoV-2 pandemic and long-range (LR) transmission is believed to play a major role. We investigated two choir outbreaks with different attack rates (AR) to analyze the contribution of LR transmission and highlight important measures for prevention.
Nov 22, 2022
Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses
(Cell Host and Microbe) Humanity has faced three recent outbreaks of novel betacoronaviruses, emphasizing the need to develop approaches that broadly target coronaviruses. Here, we identify 55 monoclonal antibodies from COVID-19 convalescent donors that bind diverse betacoronavirus spike proteins. Most antibodies targeted an S2 epitope that included the K814 residue and were non-neutralizing. However, 11 […]
Nov 21, 2022
(Journal of Infectious Diseases) Respiratory syncytial virus (RSV) is associated with acute respiratory infection. We sought to identify RSV variants associated with prolonged infection.
Nov 21, 2022
(Neurology) The relationship between COVID-19 and epilepsy is uncertain. We studied the potential association between COVID-19 and seizures or epilepsy in the six months after infection. We applied validated methods to an electronic health records network (TriNetX Analytics) of 81 million people. We closely matched people with COVID-19 infections to those with influenza. In each […]
Nov 18, 2022
Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England
(Nature) Infection with SARS-CoV-2 virus is associated with a wide range of symptoms. The REal-time Assessment of Community Transmission −1 (REACT-1) study monitored the spread and clinical manifestation of SARS-CoV-2 among random samples of the population in England from 1 May 2020 to 31 March 2022. We show changing symptom profiles associated with the different variants […]
Nov 15, 2022