Category: Published Research
Mpox poses an ever-increasing epidemic and pandemic risk
Nature The human interaction with mpox has changed across its entire endemic range, revealing the endemic and pandemic risk of monkeypox virus and the current knowledge gaps on its biology that hamper virus control. Humans are an ecological niche for orthopoxviruses (OPXV) such as mpox, a niche originally filled by smallpox (variola virus; VARV). Since […]
Apr 1, 2025
Transmission dynamics of the 2022 mpox epidemic in New York City
Nature The 2022 global mpox epidemic was caused by transmission of MPXV clade IIb, lineage B.1 through sexual contact networks, with New York City (NYC) experiencing the first and largest outbreak in the United States. By performing phylogeographic analysis of MPXV genomes sampled from 757 individuals in NYC between April 2022 and April 2023, and […]
Mar 26, 2025
Exposure and survival of wild raptors during the 2022–2023 highly pathogenic influenza a virus outbreak
Nature The global outbreak of clade 2.3.4.4b H5N1 highly pathogenic influenza A virus (HP H5N1) has had an unprecedented impact on wild birds including raptors, but long-term population impacts have not been addressed. To determine if raptors survive infections with HP H5N1, raptors from the upper Midwest United States were serologically tested for antibodies to […]
Feb 26, 2025
Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study
Journal of Internal Medicine Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may occur after infection. How often people develop ME/CFS after SARS-CoV-2 infection is unknown. Objective To determine the incidence and prevalence of post-COVID-19 ME/CFS among adults enrolled in the Researching COVID to Enhance Recovery (RECOVER-Adult) study. Design, Setting, and Participants RECOVER-Adult is a longitudinal observational […]
Jan 14, 2025
Evidence of Influenza A(H5N1) Spillover Infections in Horses, Mongolia
CDC Recent outbreaks of influenza A(H5N1) have affected many mammal species. We report serologic evidence of H5N1 virus infection in horses in Mongolia. Because H3N8 equine influenza virus is endemic in many countries, horses should be monitored to prevent reassortment between equine and avian influenza viruses with unknown consequences. Avian influenza viruses (AIVs) of the […]
Jan 7, 2025
The Emerging Threat of H5N1 to Human Health
NEJM Highly pathogenic avian influenza (HPAI) A(H5N1) emerged in 1997.1 Since then, it has spread globally by migratory birds, resulting in infections in animals on every continent. HPAI A(H5N1) clade 2.3.4.4b emerged in 2021 and resulted in fatal infections in poultry as well as terrestrial and marine mammals.1 In early 2024, influenza A infection was first recognized […]
Jan 7, 2025
Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection
NEJM Highly pathogenic avian influenza A(H5N1) viruses are circulating among wild birds and poultry in British Columbia, Canada.1 These viruses are also recognized to cause illness in humans. Here, we report a case of critical illness caused by influenza A(H5N1) virus infection in British Columbia. On November 4, 2024, a 13-year-old girl with a history of […]
Jan 7, 2025
Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor
CDC ABSTRACT We show that human myxovirus resistance protein 1 (MxA) suppresses replication of highly pathogenic avian influenza A(H5N1) viruses isolated from mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral polymerase complex components from a human-adapted MxA-resistant strain in vitro. Since 2022, clade 2.3.4.4b highly […]
Dec 10, 2024
Influenza A(H5N1) shedding in air corresponds to transmissibility in mammals
Nature An increase in spillover events of highly pathogenic avian influenza A(H5N1) viruses to mammals suggests selection of viruses that transmit well in mammals. Here we use air-sampling devices to continuously sample infectious influenza viruses expelled by experimentally infected ferrets. The resulting quantitative virus shedding kinetics data resembled ferret-to-ferret transmission studies and indicated that the […]
Dec 3, 2024
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
Nature A prospective, multicenter study of patients hospitalized with COVID-19 demonstrates objective global cognitive impairment after 12–18 months of follow-up, especially in those who had experienced encephalopathy. The cognitive impairment was associated with increased levels of serum brain injury biomarkers and a reduction in regional brain volume on MRI.
Nov 26, 2024