UNMC_Acronym_Vert_sm_4c
University of Nebraska Medical Center

Category: Published Research

Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study

Journal of Internal Medicine Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may occur after infection. How often people develop ME/CFS after SARS-CoV-2 infection is unknown. Objective To determine the incidence and prevalence of post-COVID-19 ME/CFS among adults enrolled in the Researching COVID to Enhance Recovery (RECOVER-Adult) study. Design, Setting, and Participants RECOVER-Adult is a longitudinal observational […]

Jan 14, 2025

Evidence of Influenza A(H5N1) Spillover Infections in Horses, Mongolia

CDC Recent outbreaks of influenza A(H5N1) have affected many mammal species. We report serologic evidence of H5N1 virus infection in horses in Mongolia. Because H3N8 equine influenza virus is endemic in many countries, horses should be monitored to prevent reassortment between equine and avian influenza viruses with unknown consequences. Avian influenza viruses (AIVs) of the […]

Jan 7, 2025

The Emerging Threat of H5N1 to Human Health

NEJM Highly pathogenic avian influenza (HPAI) A(H5N1) emerged in 1997.1 Since then, it has spread globally by migratory birds, resulting in infections in animals on every continent. HPAI A(H5N1) clade 2.3.4.4b emerged in 2021 and resulted in fatal infections in poultry as well as terrestrial and marine mammals.1 In early 2024, influenza A infection was first recognized […]

Jan 7, 2025

Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection

NEJM Highly pathogenic avian influenza A(H5N1) viruses are circulating among wild birds and poultry in British Columbia, Canada.1 These viruses are also recognized to cause illness in humans. Here, we report a case of critical illness caused by influenza A(H5N1) virus infection in British Columbia. On November 4, 2024, a 13-year-old girl with a history of […]

Jan 7, 2025

Replication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor

CDC ABSTRACT We show that human myxovirus resistance protein 1 (MxA) suppresses replication of highly pathogenic avian influenza A(H5N1) viruses isolated from mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral polymerase complex components from a human-adapted MxA-resistant strain in vitro. Since 2022, clade 2.3.4.4b highly […]

Dec 10, 2024

Influenza A(H5N1) shedding in air corresponds to transmissibility in mammals

Nature An increase in spillover events of highly pathogenic avian influenza A(H5N1) viruses to mammals suggests selection of viruses that transmit well in mammals. Here we use air-sampling devices to continuously sample infectious influenza viruses expelled by experimentally infected ferrets. The resulting quantitative virus shedding kinetics data resembled ferret-to-ferret transmission studies and indicated that the […]

Dec 3, 2024

Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss

Nature A prospective, multicenter study of patients hospitalized with COVID-19 demonstrates objective global cognitive impairment after 12–18 months of follow-up, especially in those who had experienced encephalopathy. The cognitive impairment was associated with increased levels of serum brain injury biomarkers and a reduction in regional brain volume on MRI.

Nov 26, 2024

Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission

Nature H5N1 high pathogenicity avian influenza virus has killed thousands of marine mammals in South America since 2022. Here we report epidemiological data and full genome characterization of clade 2.3.4.4b H5N1 HPAI viruses associated with a massive outbreak in southern elephant seals (Mirounga leonina) at Península Valdés, Argentina, in October 2023. We also report on […]

Nov 12, 2024

Nirmatrelvir plus ritonavir reduces COVID-19 hospitalization and prevents long COVID in adult outpatients

Nature Nirmatrelvir plus ritonavir received Emergency Use Authorization for treating mild to moderate COVID-19 in high-risk patients. Its efficacy against the Omicron variant of SARS-CoV-2 remains uncertain. This retrospective cohort study assessed the effect of nirmatrelvir–ritonavir in preventing severe disease progression and long COVID symptoms after acute COVID-19 in non-hospitalized adults. SALAMA medical records from […]

Oct 29, 2024

A human isolate of bovine H5N1 is transmissible and lethal in animal models

Nature The outbreak of clade 2.3.4.4b highly pathogenic avian influenza viruses of the H5N1 subtype (HPAI H5N1) in dairy cows in the US has so far resulted in spillover infections of at least thirteen farm workers1-3, who presented with mild respiratory symptoms or conjunctivitis, and one individual with no known animal exposure who was hospitalized […]

Oct 29, 2024