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University of Nebraska Medical Center

Category: Emerging Infectious Diseases

Bird flu vaccination policies by country

(Reuters) A growing number of countries are turning to vaccinations against avian influenza, commonly known as bird flu, to stem one of the world’s worst outbreaks of the deadly virus. More than 30 countries have resorted to the use of vaccination against highly pathogenic avian influenza (HPAI) since 2005, the World Organisation for Animal Health (WOAH) said, […]

Feb 17, 2023

What Bird Flu Reminds Us About Influenza Pandemics

(MedPageToday) Amesh Adalja, MD  It is inevitable that there will be a next influenza pandemic in humanity’s future. When it will occur and the identity of the culprit influenza strain are not fully answerable questions. There are myriad different avian influenza viruses constantly circulating, mutating, and regrouping in their natural waterfowl hosts. As such, the prolific […]

Feb 17, 2023

Bird flu continues to spread in mammals – what this means for humans and wildlife

(The Conversation) As bird flu continues to decimate poultry and wild bird populations around the world, the virus – a deadly strain called H5N1 – appears to be spreading to mammals. The virus has already been confirmed in foxes and otters in the UK, and more recently in four dead seals. Bird flu refers to influenza A […]

Feb 17, 2023

Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs

(PLoS Biology) Although ACE2 is the primary receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, a systematic assessment of host factors that regulate binding to SARS-CoV-2 spike protein has not been described. Here, we use whole-genome CRISPR activation to identify host factors controlling cellular interactions with SARS-CoV-2. Our top hit was a TLR-related cell […]

Feb 17, 2023

How Deadly Was China’s Covid Wave?

(New York Times) Two months after China ended “zero Covid,” rough estimates suggest that between 1 and 1.5 million people died — far more than the official count. After China relaxed the world’s most stringent Covid-19 restrictions in December, the virus exploded. Hints of the surge were everywhere: Hospitals turned away patients. Crematories were overwhelmed with […]

Feb 16, 2023

Causal Effects of COVID-19 on Structural Changes in Specific Brain Regions: A Mendelian Randomization Study

Lancet Preprint Background: Previous studies have found a correlation between coronavirus disease 2019 (COVID-19) and changes in brain structure and cognitive impairment, but it remains unclear whether COVID-19 causes structural changes to the brain and which specific brain regions may be affected. Herein, we conduct a Mendelian randomization (MR) study to determine this causal relationship […]

Feb 16, 2023

Covid-19 Is Now Harder to Stop and Easier to Survive

(Washington Post) To figure out what’s going on with Covid-19, a good place to start is in the sewers. Since early in the pandemic, the Massachusetts Water Resources Authority has been testing inflows to its Deer Island Wastewater Treatment Plant in Boston Harbor for the virus. The readings provide a remarkably detailed picture of the course […]

Feb 16, 2023

Zoonotic Mutation of Highly Pathogenic Avian Influenza H5N1 Virus Identified in the Brain of Multiple Wild Carnivore Species

(Pathogens) Wild carnivore species infected with highly pathogenic avian influenza (HPAI) virus subtype H5N1 during the 2021–2022 outbreak in the Netherlands included red fox (Vulpes vulpes), polecat (Mustela putorius), otter (Lutra lutra), and badger (Meles meles). Most of the animals were submitted for testing because they showed neurological signs. In this study, the HPAI H5N1 […]

Feb 16, 2023

Explainer: What are the bird flu risks to people and animals?

(Reuters) Countries ranging from the United States and Britain to France and Japan have suffered record losses of poultry in outbreaks of avian flu in the past year. The disease, which experts said is being spread by migratory birds, reached South American nations such as Ecuador, Peru and Bolivia for the first time. SHOULD HUMANS WORRY ABOUT INFECTIONS? The risk to humans is low, said […]

Feb 15, 2023

What Not to Ask Me About My Long COVID

(Atlantic) Before I got long COVID, I tuned out virtually all stories about it. They were tedious because I was tired of the pandemic, because we are all tired of the pandemic, because it is as familiar as rain and honestly just as dreary; I can hardly believe we once called the coronavirus novel. Today, I still tune […]

Feb 15, 2023