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University of Nebraska Medical Center

Category: Emerging Infectious Diseases

Long COVID Now Looks like a Neurological Disease, Helping Doctors to Focus Treatments

(Scientific American) The causes of long COVID, which disables millions, may come together in the brain and nervous system. Tara Ghormley has always been an overachiever. She finished at the top of her class in high school, graduated summa cum laude from college and earned top honors in veterinary school. She went on to complete […]

Feb 14, 2023

Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial

(The Lancet) WHO has identified Marburg virus as an emerging virus requiring urgent vaccine research and development, particularly due to its recent emergence in Ghana. We report results from a first-in-human clinical trial evaluating a replication-deficient recombinant chimpanzee adenovirus type 3 (cAd3)-vectored vaccine encoding a wild-type Marburg virus Angola glycoprotein (cAd3-Marburg) in healthy adults.

Feb 14, 2023

Marburg vaccine shows promising results in first-in-human study

(NIH) A newly published paper in The Lancet shows that an experimental vaccine against Marburg virus (MARV) was safe and induced an immune response in a small, first-in-human clinical trial. The vaccine, developed by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, could someday be an important tool […]

Feb 14, 2023

The Future of Long COVID

(Atlantic) In the early spring of 2020, the condition we now call long COVID didn’t have a name, much less a large community of patient advocates. For the most part, clinicians dismissed its symptoms, and researchers focused on SARS-CoV-2 infections’ short-term effects. Now, as the pandemic approaches the end of its third winter in the […]

Feb 14, 2023

For Older Americans, the Pandemic Is Not Over

(New York Times) Seniors are increasingly left to protect themselves as the rest of the country abandons precautions: “Americans do not agree about the duty to protect others.” In early December, Aldo Caretti developed a cough and, despite all his precautions, came up positive for Covid on a home test. It took his family a […]

Feb 14, 2023

Interministerial meeting coordinated by MINSABS after the health alert for Marburg hemorrhagic fever issued yesterday.

EQ Ministry of Health (Machine translated to English) Today, the Minister of Health and Social Welfare, accompanied by the presidential advisers on health, and WHO consultants based in the country, held an important meeting with the departments linked to the inter-ministerial management of the current epidemic of Marburg virus hemorrhagic fever. The Minister of State […]

Feb 14, 2023

What to know about the deadly Marburg virus as new outbreak emerges

(Washington Post) The deadly Marburg virus has surfaced this week for the first time in Equatorial Guinea, causing at least nine deaths in the west African nation, according to the World Health Organization. A handful of Marburg cases were identified in Ghana late last year. Although it remains “a very rare disease in people,” according to the Centers for Disease Control […]

Feb 14, 2023

EG MoH Statement

UPDATE STATEMENT SANITARY ALERT OF THE DAYFEBRUARY 8, 2023(Machine translated) The Government of the Republic of Equatorial Guinea, through the Ministry of Health and Social Welfare, issues the following update on the situation of the health alert of last February 8, communicated as a result of the unusual epidemiological situation detected in the districts of […]

Feb 13, 2023

WHO Urgent Marburg Meeting

(WHO) The WHO R&D Blueprint is organizing an urgent meeting with the MARVAC partners to discuss vaccine and therapeutic candidates. We will convene an urgent meeting to outline proposed research priorities towards the newly identified Marburg outbreak in Equatorial Guinea. Agenda 1- Outbreak sit rep including diagnostics and epi info2- Review of core trial protocol (Ira Longini)3- Review […]

Feb 13, 2023

New Marburg Virus Outbreak Confirmed In Equatorial Guinea

(Forbes) Equatorial Guinea has just confirmed its first outbreak of Marburg virus, one of the families of hemorrhagic fevers related to Ebola. As with last year’s outbreak in Ghana, patient specimens had to be sent to the Institut Pasteur in Senegal for confirmation, as it requires specialized testing. One of eight samples has been confirmed […]

Feb 13, 2023