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University of Nebraska Medical Center

Category: COVID

Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants

The Lancet – SARS-CoV-2 BA.4 and BA.5 lineages have been the dominant strains in most regions worldwide and are continuously gaining mutations in the receptor-binding domain. Multiple BA.4 and BA.5 subvariants with Arg346 mutations in the spike glycoprotein have been identified in various countries, such as BA.4.6, BF.7, BA.5.2.6, BA.4.1.9, and BE.1.2 harbouring Arg346Thr; BA.4.7 […]

Sep 28, 2022

Host and viral proteins involved in SARS-CoV-2 infection differentially bind heme

PubMed – In most severe cases, SARS-CoV-2-induced autoimmune reactions have been associated with hemolytic complications. Hemolysis-derived heme from ruptured red blood cells has been shown to trigger a variety of fatal proinflammatory and procoagulant effects, which might deteriorate the progression of COVID-19. In addition, the virus itself can induce proinflammatory signals via the accessory protein […]

Sep 28, 2022

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Nature – Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus Betacoronavirus. The ancestor strain has evolved into a number of variants of concern, with the Omicron variant of concern now having many distinct sublineages. The ongoing COVID-19 pandemic caused by […]

Sep 28, 2022

CDC/IDSA Clinician Call: Updates & Emerging Issues on COVID-19 and Monkeypox

IDSA – Link to download slides Topic: Updates & Emerging Issues on COVID-19 and Monkeypox Moderator:Dana S. Wollins, DrPH, MGCVice President, Clinical Affairs & Practice Guidelines, IDSA Topics and Featured Experts COVID-19: Situation Update, Emerging Variants & Implications for Therapeutics:Pragna Patel, MD, MPHCaptain, U.S. Public Health ServiceChief Medical Officer (acting)Coronavirus and Other Respiratory Diseases Division […]

Sep 27, 2022

Covid-19 Associated With 72% Greater Risk Of Type 1 Diabetes Among Children, Study Shows

Forbes – Still think that getting Covid-19 is no big deal for children? Well, there’s been growing evidence that Covid-19 could hit you right in the pancreas. And a study just published as a research letter in JAMA Network furthered the possibility that Covid-19 may somehow lead to type 1 diabetes. Since type 1 diabetes results when the […]

Sep 27, 2022

Why COVID isn’t like the flu (yet) in one brutal graph

Fortune – While the two can present with similar symptoms—like fever, cough, fatigue, sore throat, muscle aches, and headache—and are both more likely to be fatal for the elderly and immunocompromised, the comparison falls apart when it comes to the death toll. 

Sep 27, 2022

Long COVID Has Forced a Reckoning for One of Medicine’s Most Neglected Diseases

The Atlantic – Only a couple dozen doctors specialize in chronic fatigue syndrome (ME/CFS). Now their knowledge could be crucial to treating millions more patients. ME/CFS involves a panoply of debilitating symptoms that affect many organ systems and that get worse with exertion. The Institute of Medicine estimates that it affects 836,000 to 2.5 million people in the […]

Sep 27, 2022

Omicron subvariants linked to reinfections

CIDRAP – A new study based on COVID-19 patients in France shows high reinfection rates among people with different Omicron subvariants, including BA.1, BA.2, and BA.5. The study is published as a research letter in Emerging Infectious Diseases. The research group conducting this study, from Aix Marseille University, previously found reinfection rates were 6-fold higher during […]

Sep 27, 2022

Coming Soon: More Moderna Boosters, More Monoclonal Antibody Treatments

KHN – The FDA has authorized five more batches of Moderna’s updated covid shot to address shortages across the nation. And the Health and Human Services Department is buying 60,000 more doses of bebtelovimab.

Sep 27, 2022

A practical update on the management of patients with COVID–19

Royal College of Physicians – While vaccines against COVID-19 are being rolled out, an ongoing need remains for therapies to treat patients who have symptomatic COVID-19 before vaccination or in whom breakthrough infection develops. Dexamethasone and interleukin-6 inhibitors have been the mainstay of treatment for severe to critical COVID-19 requiring hospitalisation. However, in the previous […]

Sep 27, 2022