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Global Center for Health Security

- Our Expertise Overview
- Why Nebraska?
  Nebraska’s difference is an all-star, all-volunteer team that dedicated itself to being ready for any biocontainment crisis at any time.
- Leadership
  The Global Center is led by experts in biopreparedness and high-consequence infections research, education and clinical care.
- Scholars
  Our scholars are leading advancements in global health security.
- Affiliates
  Our affiliates are innovative experts collaborating to advance global health security.
- C-STARS
  C-STARS, the Center for Sustainment of Trauma Readiness Skills- Omaha is a collaboration between UNMC, Nebraska Medicine, and the Air Force Research Laboratory’s School of Aerospace Medicine. C-STARS Omaha works closely with UNMC’s Global Center for Health Security, iEXCEL, and the Nebraska Biocontainment Unit to take advantage of the medical center’s capabilities and expertise in biopreparedness training and research.
- Our Team
  Our team consists of a variety of professionals providing support and project management to further the Global Center for Health Security’s mission.
- Domains Overview
- Clinical
  The Global Center for Health Security is the premier U.S. institution for management of high-consequence infections. Further, our clinical capabilities include biological, chemical, burn, and radiation domains.
- Education & Training
  Our expertise is now sought worldwide and officially sanctioned by the U.S. government. The GCHS is the home base to the national Training, Simulation, and Quarantine Center and the Nebraska Biocontainment Unit.
- Research
  The GCHS has laser-focused existing work by our leading scientists in fields like chemical weapons, drug discovery and public health.
- Innovation & External Partnerships
  The GCHS has partnered with many academic groups at UNMC and external partners to tackle the most pressing problems in emerging infectious diseases.
Programs
- Health Emergencies Overview
- Outbreaks to Watch
  Find information about emerging pathogens, diseases and outbreaks from around the world. Stay updated on the most recent information on worldwide global health and emerging pathogens outbreaks.
- COVID-19
  Explore our COVID-19 page for recent news, resources, manuals, and playbooks. Biweekly overviews of new data and developments presented by James V. Lawler, MD, MPH, FIDSA can now be found on the Health Emergencies page.
- HPAI H5N1- Avian Influenza
  Learn more about the current worldwide outbreak of HPAI H5N1- Avian Influenza and explore resources, news, webinars, and our unofficial map.
- Measles
  Explore this page for more information, resources, and news about the current global measles outbreak.
- MPox
  The Global Center for Health Security is currently monitoring the spread of Mpox. Learn more by viewing our resources.
- RSV
  This page provides information, news, and resources about Respiratory syncytial virus (RSV).
The Transmission
- News Overview
- Highlights
  Read recent highlights, articles, events, recognition and updates on the work of our programs and partners.
- Events
  Find scheduled and past events involving the Global Center for Health Security.
- Annual Reports
  Find annual reports for our center and several of our programs.

— Global Center for Health Security — The Transmission — Category: Avian Influenza Published Research

Category: Avian Influenza Published Research

Avian Influenza Published Research

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

(Nature) Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans, but currently do not transmit efficiently among humans. The viral haemagglutinin (HA) protein is a known host-range determinant as it mediates virus binding to host-specific cellular receptors1,2,3. Here we assess the molecular changes in HA that would allow a virus possessing subtype H5 HA […]

May 2, 2012

Avian Influenza Published Research

In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity

(Virology) Acquisition of α2-6 sialoside receptor specificity by α2-3 specific highly-pathogenic avian influenza viruses (H5N1) is thought to be a prerequisite for efficient transmission in humans. By in vitro selection for binding α2-6 sialosides, we identified four variant viruses with amino acid substitutions in the hemagglutinin (S227N, D187G, E190G, and Q196R) that revealed modestly increased α2-6 and […]

Jan 5, 2012