Author: Claudinne Miller
Nature Adjuvant-containing subunit vaccines represent a promising approach for protection against tuberculosis (TB), but current candidates require refrigerated storage. Here we present results from a randomized, double-blinded Phase 1 clinical trial (NCT03722472) evaluating the safety, tolerability, and immunogenicity of a thermostable lyophilized single-vial presentation of the ID93 + GLA-SE vaccine candidate compared to the non-thermostable two-vial vaccine […]
Mar 7, 2023
Temperature-Stable TB Vaccine Safe, Prompts Immune Response in NIH-Supported Study
NIH A clinical trial testing a freeze-dried, temperature-stable experimental tuberculosis (TB) vaccine in healthy adults found that it was safe and stimulated both antibodies and responses from the cellular arm of the immune system. The Phase 1 trial was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes […]
Mar 7, 2023
What Scientists Know About Long COVID, 3 Years In
C-Net A puzzling disease left millions of patients trying to piece it together. Research is ongoing, but some causes and potential treatments are taking shape. For many people, what started out as a relatively mild case of COVID-19 persisted into a lingering condition that took weeks or months before their suffering subsided — some are […]
Mar 7, 2023
France reports bird flu in foxes near Paris, WOAH says
Reuters France has reported an outbreak of highly pathogenic H5N1 bird flu among red foxes northeast of Paris, the World Organisation for Animal Health (WOAH) said on Tuesday, as the spread of the virus to mammals raised global concerns. After three foxes were found dead in a nature reserve in Meaux near where gulls had […]
Mar 7, 2023
JAMA Question Do postacute sequelae of SARS-CoV-2 increase risks of 1-year adverse outcomes? Findings In this case-control study of 13 435 US adults with post–COVID-19 condition (PCC) and 26 870 matched adults without COVID-19, the adults with PCC experienced increased risks for a number of cardiovascular outcomes, such as ischemic stroke. During the 12-month follow-up period, 2.8% of the […]
Mar 7, 2023
Which Adults Need Polio Boosters
Precision Vaccinations The U.S. Centers for Disease Control and Prevention (CDC) vaccine advisory committee is discussing how to make the current polio vaccination recommendations easier to understand. On February 23, 2023, Sarah Kidd, M.D., MPH, presented to the Advisory Committee on Immunization Practices (ACIP) proposed language for adult polio vaccinations in the U.S. The CDC’s current recommendations for […]
Mar 7, 2023
Long Covid Patients More Likely to Have Gastrointestinal Problems, Study Finds
New York Times The study, which examined patients infected early in the pandemic, found they were significantly more likely than people who didn’t get Covid to experience lingering reflux, constipation and other issues. Stomach pain, constipation, diarrhea, vomiting, bloating — these are symptoms frequently reported by people with long Covid. Now, a large new study reports that […]
Mar 7, 2023
Metformin found to reduce Long Covid in clinical trial
Inside Medicine A study posted on a preprint server operated by the medical journal The Lancet reports that Long Covid diagnoses were found to be lower in patients who received metformin (an inexpensive diabetes drug) compared to those who received placebo. The study has not yet been peer reviewed. Still, the findings are promising. Around 10.6% (1 in 9) […]
Mar 7, 2023
CDC Releases Important Updates on COVID
(CDC) In the acute phase, clinical manifestations and complications of COVID-19 of varying degrees have been documented including death. However, patients who recover from the acute phase of the infection can still suffer long-term effects (8). Post-acute sequelae of COVID-19 (PASC), commonly referred to as “long COVID,” refers to the long-term symptoms, signs, and complications […]
Mar 7, 2023
Lion infected with covid-19 probably passed it on to two zoo workers
New Scientist A lion at Potawatomi Zoo in South Bend, Indiana, tested positive for the SARS-CoV-2 coronavirus after it started coughing and became breathless. Zoo workers who had cared for the lion later caught the infection. A lion that was infected with the coronavirus probably passed it on to two zoo employees, researchers have said […]
Mar 7, 2023