Key Points
Question What variables are associated with time to recovery from SARS-CoV-2 infection?
Findings In this cohort study of 4708 participants in a US meta-cohort, the median self-reported time to recovery from SARS-CoV-2 infection was 20 days, and an estimated 22.5% had not recovered by 90 days. Women and adults with suboptimal prepandemic health, particularly clinical cardiovascular disease, had longer times to recovery, whereas vaccination prior to infection and infection during the Omicron variant wave were associated with shorter times to recovery.
Meaning These findings suggest that interventions to reduce severity of acute infection, such as vaccination, may help to mitigate the increased risk of persistent symptoms observed in women and adults with suboptimal prepandemic health.