CBC Older lab studies showed flu viruses like H5N1 can spread through unusual routes, but may have been overlooked.
When U.S. dairy cows began falling ill with a dangerous form of bird flu, many scientists were struck by an unusual pattern: The virus kept showing up in cows’ udders, of all places.
Influenza is usually known as a respiratory virus, entering the body through the throat and nose before heading to the lungs. But Canadian virologist Alyson Kelvin wasn’t among those shocked by the udder discovery.
“We’ve known that the cow mammary gland is susceptible to influenza virus infections since at least the ’50s,” said Kelvin, a longtime influenza researcher who works at the University of Saskatchewan’s Vaccine and Infectious Disease Organization. “So this isn’t that surprising.”
Indeed, decades of scientific study provided early clues that something like this was possible.
Even though 2024 marked the first time H5N1, a form of influenza A, was reported in dairy cows, researchers knew influenza viruses can target the cells that make up mammary glands.
The little-understood transmission pathway may have also played a role in two human infections linked to the current U.S. outbreak — both of which only involved eye infections, possibly from the virus entering the eye membranes through contaminated milk.
“I think if we paid more attention to [these possibilities],” Kelvin said, “we might have not been so surprised.”
Early research showed flu can infect cow udders
So far, cases among U.S. dairy cows have officially spread to more than 50 herds across nine states.
But multiple scientists who spoke to CBC News in recent weeks say sluggish data-sharing and limited testing — and the detection of harmless viral fragments in the country’s processed milk supply — suggest the virus is already more widespread. Genetic sequencing of the virus, showing its evolution, also suggests H5N1 was likely circulating in cows months before the first cases were discovered in March.