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University of Nebraska Medical Center

NIH-sponsored trial of Lassa vaccine opens

NIH

Lassa fever is a viral hemorrhagic disease that can be fatal and that causes permanent hearing loss. A National Institutes of Health (NIH)-sponsored clinical trial of a candidate vaccine to prevent Lassa fever has begun enrolling participants at the University of Maryland School of Medicine, Baltimore. Lassa fever is a viral hemorrhagic disease that can be fatal and that causes permanent hearing loss in up to one-third of those who contract it. Lassa virus is spread by rodents, known as multimammate rats, that are native to many countries in West Africa. The virus can also be spread from person to person. Currently, there are no specific drug treatments or vaccines for Lassa fever. NIH’s National Institute of Allergy and Infectious Diseases (NIAID) is sponsoring the Phase 1 trial.

“The candidate vaccine being tested in this trial was developed by an NIH-supported research team at Thomas Jefferson University in Philadelphia,” said NIAID Director Jeanne Marrazzo, M.D., M.P.H. “The progression of this candidate from the lab to a first-in-humans clinical trial is a promising step towards a vaccine to prevent Lassa fever.”  

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