MedPageToday Only “traces” of spike-specific salivary antibodies found in vaccinated SARS-CoV-2-naive people.
COVID-19 mRNA vaccines stimulated mucosal immunity in people previously infected with SARS-CoV-2, but generated only a tiny amount of immunity in people who had never been infected, according to a cohort study using data from the French CoviCompare trials.
Among trial participants who received the Moderna mRNA-1273 (Spikevax) vaccine in early to mid 2021, SARS-CoV-2 spike-specific saliva IgA levels were significantly higher in those with previous infection compared with the most responsive SARS-CoV-2-naive participants at day 180 (P<0.001), reported Guy Gorochov, MD, PhD, of Sorbonne University in Paris, and colleagues in JAMA Network Open