How your first brush with COVID warps your immunity

(Nature) The immune system responds more strongly to the strain of a virus that it first met, weakening response to other strains. Can this ‘imprinting’ be overcome? During the summer of 2022, with the Omicron coronavirus variant running rampant, friends and relatives of immunologist Bob Seder kept asking him if they should postpone their COVID-19 boosters and wait for the new Omicron-tailored vaccine to become available. He told them not to delay.