Are Subphenotypes for Long COVID Beneficial?

(MedPageToday) A recent study opens in a new tab or window published in Nature Medicine, “Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes” by Hao Zhang, PhD, et al. used a data-driven framework to stratify patients suffering with post-acute SARS-CoV-2 (PASC), also referred to as long COVID, into different subcategories of sequelae. The bulk of the patients in the study were categorized as “subphenotype 1” — these were the sickest patients, and had cardiac and renal involvement. A close second was “subphenotype 2,” which included patients with respiratory and concomitant sleep dysfunction and anxiety symptoms. “Subphenotype 3” patients had predominant neurological and musculoskeletal presentation, and the final, and smallest category was “subphenotype 4,” including patients with significant digestive symptoms. [Link to Study]