Jordan Rowley, PhD
Associate Professor, Department of Genetics, Cell Biology, and Anatomy
Director, Bioinformatics & Systems Biology PhD Program
Dr. Rowley is an expert in epigenetics, genomics, and bioinformatics, with a laboratory that uses a combination of wet-lab experimentation, bioinformatics analysis, and software development. In research, he is an advocate for model organisms and the importance of uncovering basic mechanisms. He is also deeply committed to teaching and advancing the educational programs of UNMC. He currently directs the Bioinformatics & Systems Biology (BISB) PhD program and is faculty advisor to UNMC's Bioinformatics Club.
- Post-doc, Emory University
- PhD, University of Michigan
Methods
We primarily use genomic methods, including derivations of Hi-C, ATAC-seq, CUT&RUN, and RNA-seq to study features of chromtin organization. We are particularly interested in innovating both the methodolgy and the analysis that is commonly used to study chromatin architecture in order to understand genome organization at sub-kilobase resolution. We are currently investigation topics that include chromosome pairing, transcription associated gene loops, and aberrant chromatin looping within fetal alcohol spectrum disorder.
Software Development
Part of our work is to develop novel algorithms and easy to use tools for the analysis of genomics data, particuraly data obatined by Hi-C or its derivatives.
Model Systems
We are advocates of using model organisms, which are essential for progress in genetics and have been instrumental in discovering principles of genome organization. We have worked in plants, worms, and flies, each of which has similar and distinct ways of organizing their genome. Understanding these principles is helping to uncover the basic rules of chromatin architecture.
- K99/R00 Pathway to Independence Award, NIGMS, 2018 - 2022
985805 Nebraska Medical Center
Omaha, NE 68198-5805