Clinical Trials and Grants

Current Trials

• June 2024 to present, POST-ICECAP - Patterns of survivors’ recovery trajectories in the ICECAP trial. NHLBI/NINDS funded.
• February 2024 to present, “A comparative evaluation of wound healing when using 3D printed suture material and commercial suture materials.” Basic science study, department funded.
• June 2023 to present, “HAVOC (Hyperbaric oxygen therapy in sickle cell pain crisis. Department funded.
• January 2023 to present, “Sous vide frost bite trial.” Multi-center frostbite trial.
• March 2021 to present, “ICECAP: Influence of cooling duration on efficacy in cardiac arrest patients”. NHLBI/NINDS funded (SIREN Network).

Grants

• Optogenetic silencing to achieve antiarrhythmic effect of renal denervation in chronic heart failure. NIH/NHLBI, 1R01169476-01. Contact-principal investigator: Yu-Long Li, MD, PhD. 09/01/2023 to 08/31/2028. $3,675,705.
• Mechanisms of cardiac sympathetic hyperactivity in chronic heart failure. NIH/NHLBI, 2R01HL137832-05. Principal investigator: Yu-Long Li, MD, PhD. 01/01/2023 to 12/31/2026. $2,593,643. 
• Neuromuscular junction as a therapeutic target to improve post-traumatic outcomes. NIH/NIGMS, 1R01GM145736-01. Principal investigator: Yu-Long Li, MD, PhD. 07/01/2022 to 04/30/2026. $1,504,300.  
• Potential therapies to improve ventricular vagal function in Type 2 diabetes. NIH/NHLBI, 1R01HL144146-04. Principal investigator: Yu-Long Li, MD, PhD. 08/01/2018 to 07/31/2024. $1,525,000.
• Optogenetic activation of cardiac vagal neurons as a potential therapy for fatal ventricular arrhythmia in heart failure. Transformational Project Award from American Heart Association, 23TPA1064315. Principal investigator: Yu-Long Li, MD, PhD. 07/01/2023 to 06/30/2026. $300,000.
• Deciphering a novel lncRNA-mediated lipid droplet transport system in human heart. NIH/NHLBI, 1R01HL160856-01A1. Co-investigator: Yu-Long Li, MD, PhD, 5% effort. 08/01/2022 to 07/31/2026. $2,166,092.
• Optogenetic modulation of cardiac vagal function improves prognosis in diabetes. NIH/NHLBI, 1R21HL163509-01A1. Co-investigator: Yu-Long Li, MD, PhD, 10% effort. 08/01/2023 to 07/31/2025). $422,125.
• Cardiac postganglionic sympathetic neurons and antiarrhythmic effect of renal denervation in chronic heart failure. Career Development Award from American Heart Association, 851929. Mentor: Yu-Long Li, MD, PhD. 07/01/2021 to 06/30/2024. $230,901.
• Novel target mechanism (renal denervation) to reduce sodium retention in chronic heart failure. NIH/NIDDK, 1R01DK114663. Co-investigator: Yu-Long Li, MD, PhD, 5% effort. 08/15/2017 to 04/30/2024. $2,072,021.
• Potential mechanisms underlying parasympathetic neuronal dysfunction in diabetes. NIH/NHLBI, 1R01HL168500-01A1. Principal investigator: Yu-Long Li, MD, PhD. 12/01/2023 to 11/30/2028. $3,016,630 (pending, 5% percentile, payline being 14% percentile).
• Hyperbaric oxygen therapy improves outcomes in post-traumatic extremity injuries. USAMRDC grant from Department of Defense, W81XWH-18-SBAA1-220004. Principal investigator: Yu-Long Li, MD, PhD. 12/01//2023 to 11/30/2026, (pending, 1.9 score).
• United States Japan Foundation Grant (Thang Thanh Nguyen, PhD; Aaron Barksdale, MD; Wesley Zeger, DO; and Michael Wadman, MD), 2019 to present. $198,880.
• Nebraska Department of Economic Development Fund (Thang Thanh Nguyen, PhD), 2023 to present. $75,000.
• NIH Continuum Education Technologies Grant (Thang Thanh Nguyen, PhD), 2024 to present. 25,000.
• Nebraska Department of Economic Development Fund (Thang Thanh Nguyen, PhD), 2024 to present. $25,000.