Sarah Holstein, MD, PhD - Professor
Research Interests:
Osteosarcoma, Ewing Sarcoma, Novel Agent
Current Research Summary:
My laboratory focuses on the development of novel small molecules with anti-cancer properties. A major focus revolves around the development of novel geranylgeranyl diphosphate synthase inhibitors as a means to inhibit Rab function and disrupt intracellular trafficking processes. While the primary disease focus has been multiple myeloma (my clinical specialty), my group has explored the activity of our lead agent in osteosarcoma and Ewing sarcoma cell lines. The promising activity of our drug in these malignancies led to a funded pilot grant from the cancer center/CHRI and the ongoing project has in turn led to a subsequent extramural grant application as well as a manuscript which is about to be submitted. In addition, another class of small molecule agents called tropolones have been studied in my laboratory in osteosarcoma and Ewing sarcoma. This work led to a collaboration with Drs. James Ford and DJ Murry which resulted in Dr. Ford receiving a grant from the Hyundai Hope on Wheels Foundation to continue this work. This grant is ongoing.