The Fred & Pamela Buffett Cancer Center

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- Research Overview
- - Membership Directory
    Search a listing of full members of the Fred & Pamela Buffett Cancer Center, as well as directories of members by research program.
  - Membership Criteria
    Learn about the criteria for becoming a member of the Fred & Pamela Buffett Cancer Center.
  - Become a Member
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- - Shared Resources
    The Fred & Pamela Buffett Cancer Center is home to state-of-the-art facilities and provides support to shared resources at UNMC.
  - UNMC Cores and Shared Resources
    Researchers also have access to shared resources through the UNMC Office of the Vice Chancellor for Research.
  - Request Research Space
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  - Research Funding Opportunities
    NCI-designated Fred & Pamela Buffett Cancer Center supports Principal Investigators through pilot grants and seed funding to explore novel research ideas and engage in team science projects that address critical cancer care and treatment challenges.
- - Cancer Biology Program
    The Fred & Pamela Buffett Cancer Center Cancer Biology Program represents a long-standing commitment to cancer mechanisms-focused research.
  - Targets, Modulators and Delivery Program
    This program develops and delivers small molecules to modulate validated cancer targets as eventual cancer therapeutics.
  - Cancer Prevention & Control Program
    This program aims at identifying and understanding the factors influencing cancer risk, with a special emphasis on disparities and rural populations in the catchment area.
- - Registries
    View registries that are currently enrolling subjects through iCaRe2.
  - Information for Patients
    Participation helps researchers understand specific cancer types, determine risk factors, advance treatment for patients and discover cancer prognostic markers.
  - Information for Researchers
    iCaRe2 aims to foster clinical and epidemiological studies and accelerate the secondary use of cancer and health related data for translational research.
  - Information for Sponsors
    Your gift will support the continuous system growth and improve strides in personalized medicine, diagnosis, treatment and prevention of cancer.
- Community Outreach Overview
- Mission
  The Community Outreach and Engagement Office aims to reduce overall cancer burden and eliminate cancer-related health disparities in its catchment area.
- Community Advisory Board
  This board advises on the direction of cancer center research, dissemination of evidence from ongoing research activities, and policy recommendations.
- Speaker's Bureau
  The Fred & Pamela Buffett Cancer Center Speakers Bureau provides resources to community groups across Nebraska including experts to give presentations on cancer-related topics.
- Resources
  The Community Outreach and Engagement Office provides such resources as videos, infographics, reports and community needs assessments.
- Our Team
  Find members of the Community Outreach and Engagement Office team.
- Nebraska Breast Health Navigation Program
  This program is working to eliminate barriers for breast cancer survivors, using trained volunteers called Lay Patient Navigators who provide peer-to-peer support.
- Training & Education Overview
- Upper Midwest Emerging Scholars Exchange Program
  Learn about a new opportunity for Early Stage Investigators to share their research at peer institutions.
- Leadership Overview
- Director's Message
  Read a message from Joann Sweasy, PhD, director of the Fred & Pamela Buffett Cancer Center.
- About the Center
  Learn about the mission and vision of the Fred & Pamela Buffett Cancer Center.

— The Fred & Pamela Buffett Cancer Center — Research — Shared Resources — Bioinformatics Shared Resource

Bioinformatics Shared Resource

Bioinformatics

The Fred & Pamela Buffett Cancer Center (FPBCC) Bioinformatics Shared Resource fosters research and teaching activities related to bioinformatics and systems biology.

Bioinformatics Shared Resource Specific Aims:

Develop the needed infrastructure to provide up-to-date bioinformatic data analysis services.

Provide expert consultation, access to resources and data analysis services to meet the bioinformatic needs of FPBCC investigators.

Equipment:

Husker HPC Cluster with 6 nodes- 432 Cores, up to 1 TB RAM/node and up to 1 Petabyte storage space

Two GPU Lambda servers with 64 Cores, 16 GPUs and up to 1.5 TB RAM and 24 GB of VRAM/GPU

Five Virtual Machines (VMs) for custom use

Services:

Primary analysis of NGS and multiome datasets (whole genome/exome, transcriptome, epigenome, metagenome, single cell multiome)

Analysis of public domain datasets such as TCGA, ICGC and TARGET, and downstream characterization of genes and gene products

ML/DL/AI applications for cancer subtyping, prognostic prediction, and biomarker identification

Grant support – consultation on experimental design, data access, data deposition, support letters

Find more information on: Services, Pricing and Request Form

Impact

Bioinformatics

The Bioinformatics Shared Resource is located in the Durham Research Center I, allowing 80% of the FPBCC members easy access.

The Bioinformatics Shared Resource is instrumental in offering pilot support for high-performance computing infrastructure, enabling virtual screening of ultra-large compound libraries with local resources.

It has also contributed to the development of several online and cloud-based bioinformatics training modules, as well as ML/AI tools for cancer subtyping.

Director

Babu Guda, PhD

Director, Bioinformatics Shared Resource