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University of Nebraska Medical Center

Cancer Biology Program

This program represents a long-standing commitment to cancer mechanisms-focused research.

The vision of the program is to understand the fundamental mechanisms that underlie cancer initiation and progression and to interface with other programs of the Fred & Pamela Buffett Cancer Center  – including the Targets, Modulators and Delivery Program, and the Cancer Prevention & Control Program – that are positioned to translate these findings into new biomarkers and therapeutic targets, thereby positively impacting diagnosis, prevention, and treatment across cancers prevalent in our catchment area.

Co-Leaders

Elizabeth Bruce Professor of Cancer Research, UNMC Eppley Institute for Research in Cancer and Allied Diseases
Director of the Center for Breast Cancer Research
Research focus: Molecular Control of Tyrosine Kinase Signaling: Cell Biology and translation

402-559-8572

Hamid Band

Professor, UNMC Eppley Institute for Research in Cancer and Allied Diseases
Research focus: Cell proliferation; prostate and pancreatic cancer

402-559-5596

Jixin Dong

Themes and Goals

The Cancer Biology Program is organized into three themes and goals:

  1. Genome instability and cancer
    • Discover alterations of molecular mechanisms that maintain intact genomes.
  2. Signaling mechanisms in cancer
    • Discover alterations in intracellular signaling and tumor cell-microenvironment interactions.
  3. Cellular basis of cancer
    • Using in vitro and animal models, validate cancer mechanisms, biomarkers and targets.