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University of Nebraska Medical Center

Colorectal Cancer

Colorectal cancer

Understanding Colorectal Cancer

Colon cancer is a cancer that starts in the colon or rectum. It often begins as small growths called polyps in the lining of the large intestine. While most polyps are harmless, some can become cancerous over time. Since polyps usually don’t cause symptoms, regular screening is key to detecting and removing them early, making colon cancer one of the most preventable and treatable cancers.  

Key Facts About Colon Cancer
  • How common is it? Colon cancer is the third most common cancer diagnosed in both men and women in the U.S. It is also the second leading cause of cancer death, often developing without noticeable symptoms. 
  • Who is at risk? While colon cancer can affect anyone, the risk increases with age, personal or family history, and certain lifestyle factors like diet, obesity, and smoking. Cases are also rising in adults under 50, prompting updated screening guidelines that now recommend starting at age 45. 
  • Living with Colon Cancer: Early detection through screening can reduce mortality by up to 68%. Thanks to medical advancements, survival rates have significantly improved, especially when caught early. 

Common Symptoms of Colon Cancer 

  • Changes in bowel habits (diarrhea, constipation, or narrowing of stool lasting more than a few days). 
  • A persistent feeling of needing to have a bowel movement. 
  • Blood in the stool (dark brown, black, or bright red). 
  • Abdominal cramping or pain. 
  • Unexplained weight loss. 
  • Fatigue or weakness. 
  • Anemia (low blood count due to hidden bleeding in the stool). 

If you experience any of these symptoms, consult a doctor as soon as possible. 

Colon Cancer Risk Factors

Lifestyle factors that increase risk: 

  • Being overweight or obese 
  • Type 2 diabetes 
  • Diet high in red and processed meats 
  • Vitamin D deficiency 
  • Tobacco use 
  • Moderate to heavy alcohol consumption 

Risk factors you cannot change: 

  • Age over 50 
  • Personal or family history of colon cancer or polyps 
  • Personal history of inflammatory bowel disease 
  • Previous radiation therapy to the abdomen or pelvis 
  • Genetic conditions like Lynch syndrome or familial adenomatous polyposis (FAP) 

The Bottom Line: Regular screening, a healthy lifestyle, and knowing your risk factors can help prevent colon cancer or catch it early when it’s most treatable. 

Preventing and Detecting Colon Cancer

There are several screening options, ranging from at-home stool tests to colonoscopies starting at age 45:  

Visual tests:  

  • Colonoscopy (every 10 years): Detects and removes precancerous polyps before they turn into cancer. 
  • CT Colonography (every 5 years): A less invasive imaging option to examine the colon. 

Stool-based tests:

  • Detect blood or DNA markers in stool samples.  
  • FIT or FOBT – every year  
  • Cologuard – every 3 years  

Blood-based tests: Newer tests that detect specific DNA markers linked to colon cancer. 

  • Shield – every year  

Talk to your doctor about which screening test is right for you based on your risk factors. 

What You Need To Know

No, but some polyps can turn into cancer over time. Removing them helps prevent cancer. 
Yes! Eating a lot of red or processed meats and not enough fiber can increase your risk. A diet rich in fruits, vegetables, and whole grains can help lower your chances of developing colon cancer. 
It can be but catching it early through screening improves the chances of successful treatment. 
Yes! Eating healthy, staying active, avoiding smoking, and getting regular screenings can help reduce your risk. 
Absolutely. Screening is meant for people without symptoms to catch problems early. 
Yes. Most people who develop colon cancer do not have a family history of it. 
No. While it is more common in people over 50, younger adults can get it too. 
Most health plans cover screening tests for colon cancer. 

 

  
No. You will receive medication to keep you comfortable, and most people do not feel anything. 
Not necessarily. Many polyps are not cancerous, and they can often be removed during a colonoscopy. 
No. A positive result means more testing, like a colonoscopy, is needed to find out what is going on.
Yes. Both men and women are at risk and should get screened. 

ASK UNMC! What are the signs and symptoms of colon cancer?