CHEMISTRY FACULTY SEARCH

The Eppley Institute for Research in Cancer at the University of Nebraska Medical Center seek talented investigators in chemical biology and medicinal chemistry for full-time tenure-leading faculty positions with open rank (Assistant, Associate or Full Professor). Faculty rank and compensation depend upon qualifications. EEO/AA individuals from diverse backgrounds are encouraged to apply. To apply, go to https://jobs.unmc.edu and reference requisition #2017-210. Please contact Cindy Plate, cjplate@unmc.edu, with questions.

The Eppley Institute currently has 27 tenured or tenure-track faculty members. For more information about the Institute see: https://www.unmc.edu/eppley/
The successful candidate is expected to:

  1. Develop an independent, extramurally-funded research program in basic/translational cancer research that is complementary to existing strengths and aligned with the overall directions of the NCI-designated Fred & Pamela Buffett Cancer Center (FPBCC).
  2. Participate in graduate-level teaching in the Cancer Research Doctoral Program and/or other UNMC graduate programs, and engage in institutional service based on their expertise.
  3. Function as an active and collaborative participant in the FPBCC.

In addition to state of the art facilities available for biochemistry, cell and molecular biology and animal models of experimental cancer the Eppley Institute and the FPBCC also offer extensive Chemistry related resources:

The chemistry space is located on the 5th floor of the Scott Research Tower with in the FPBCC. There are 16 fume hoods (6 ft), four modules dedicated to molecular biology, four dedicated cell biology, and 2 shared instrumentation rooms. The 5th floor is also home to the high throughput screening facility and the
X-ray crystallography facility.

Shared instrumentation: The instrument laboratory houses the following: (1) Aapptech parallel synthesizer, (2) Agilent Analytical Liquid Chromatography Mass Spectrometer (LCMS) system connected to a photo diode array (PDA), fluorescence detector, and a evaporative light scattering detector (ELSD) (3) Agilent preparative LC purification system with a UV detector, autosampler and fraction collector, (4) Nicolet IR200 FT- IR Spectrometer, (5) an Aaptech freeze dryer with a -110C trap, and (6) Molecular Devices Spectromax M5 monochromatic plate reader with absorbance, luminescence, fluorescence, fluorescence resonance energy transfer (FRET) and fluorescence polarization capability. The plate reader accepts plates up to 384 wells and has both top and bottom read capabilities.

Mass Spectrometry and Proteomics Core Facility (MSPCF): The MSPCF is a state-of-the-art proteomics core serving the needs of the UNMC research community. Current instrumentation includes an Orbitrap Fusion-Lumos with ETD (Thermo) and Dionex U3000 RSLCnano liquid chromatography, 5600 TripleTOF (AB Sciex) with Eksigent cHiPLC-Nanoflexliquid chromatography, 5500 QTRAP (AB Sciex) with Shimadzu uHPLC, and 4800 MALDI TOF/TOF. The recently acquired Fusion-Lumos ETD has a brighter ion source and high-field Orbitrap analyzer, which increases speed, sensitivity and dynamic range. The Dionex U3000 RSLCnano liquid chromatography system is equipped with an interchangeable flow selector allowing easy switching between nano and micro flow to accommodate both proteomic and metabolomic analyses on the Fusion-Lumos. This system offers three complementary fragmentation techniques in one instrument: CID, HCD and ETD for definitive protein/peptide characterization with top-down or middle-down sequencing of proteins and peptides. Refined post-translational modification localization is achieved through advanced EThcD fragmentation workflows. In addition to the instrumentation, the MSCPF's staff scientists are available to provide consultation, training, and sample preparation support to the Core users. The MSCPF also maintains bioinformatics software packages necessary for the analysis of obtained mass spectra, including Proteome Discoverer, Mascot, Scaffold, Protein Pilot SEQUEST, Cytoscape, and SAINT.

NMR: The UNMC Eppley Institute NMR Facility consists of three spectrometers (a Bruker Avance III 400-MHz, Varian INOVA 500 MHz and a Varian INOVA 600 MHz with cryoprobe NMR spectrometers).

Fred & Pamela Buffett Cancer Center


The Fred & Pamela Buffett Cancer Center is in a dynamic growth phase and committed to expansion of all its research programs. A state-of-the-art $335 million complex for the Fred & Pamela Cancer Center, including a 260,000 sq. ft. cancer research tower, a multidisciplinary outpatient clinic (surgical, medical, and radiation oncology), and a 108 bed inpatient cancer hospital opened in 2017.
The FPBCC has over 100 primary members focused on externally funded research and organized into three main programs:

For more information about the Cancer Center see: http://www.unmc.edu/cancercenter.