College of Medicine

- Admissions Overview
- - MD Program
    UNMC's rigorous academics, diverse clinical experiences and supportive environment put you on the path to becoming a skilled, compassionate physician.
  - How to Apply
    UNMC prepares medical degree students to meet the needs of patients through clinical practice, biomedical science and research, problem-solving and compassion.
  - Contact Us
    Review contact information for the Office of Admissions and Student Affairs in the College of Medicine at UNMC.
  - Verification and State Licensure
    Review opportunities for state licensure following completion of the MD program in the College of Medicine at UNMC.
- - MD-MBA Program
    A combined MD-MBA degree equips you with the tools you need to become highly skilled in both management and medicine.
  - MD-MPH Program
    Pursue your passion for public health and medicine with a combined MD-MPH and help solve complex health problems.
  - MD-PhD Program
    Do you have a passion for caring for patients and for research? Consider the dual MD-PhD degree.
- Education Overview
- - Curriculum
    Our curriculum produces physicians whose foundation in basic, clinical, and health systems sciences prepare them to promote health and reduce patient suffering.
  - Graduation Requirements
    Review requirements for students pursuing an MD at the UNMC College of Medicine to graduate and receive their degree.
  - Objectives
    The objectives of UNMC's medical degree program are to prepare you for success in primary care or specialty fields.
  - Service Learning
    Active participation in community service provides critical opportunities to apply skills and knowledge gained in medical school and develop a sense of empathy.
- - Enhanced Medical Education
    Enhanced Medical Education Tracks offer medical students an opportunity to perform an in-depth study of an interdisciplinary field of medicine.
  - Enhanced Medical Education Tracks
    EMET applicants are selected for Tracks based on their interest in the topic and motivation to complete work above and beyond the primary MD curriculum.
  - MD Honor’s Thesis Program
    The MD honors thesis encourages students to engage in scientific research during medical education and become eligible to graduate with honors.
- Research Overview
- Internal Grants
  The College of Medicine has a variety of research-related grant and award opportunities available to UNMC faculty.
- Comparative Effectiveness Research
  The Comparative Effectiveness Research (CER) program identifies knowledge gaps in the effectiveness of clinical care and improves CER in these areas.
- Great Plains IDeA-CTR
  The Great Plains IDeA-CTR is a collaborative effort between nine regional institutions that provides training, resources. and funding to regional researchers.
- Research and Development Committee
  The Research and Development Committee handles funding opportunities for faculty, including the Bridge Funding program, and student research opportunities.
- Student Opportunities
  The College of Medicine provides a variety of research opportunities for both current and prospective UNMC students.
- Residencies & Fellowships Overview
- Graduate Medical Education Programs
  UNMC's dozens of programs--including nearly 20 in internal medicine--allow residents and fellows a variety of specialties.
- House Officer Resources
  Find information for residents and fellows, including salaries, benefits and nearby housing.
- House Officer Wellness
  Wellness resources for residents and fellows include an assistance program and a private wellness lounge.
- Research
  We aim to facilitate house officers’ involvement in research in the areas of patient safety, quality improvement, healthcare disparities and education research.
- Salary and Benefits
  Paid vacation and professional leave, health insurance and meal allowances are just a few of the benefits residents receive in addition to their yearly salary.
- Contact Us
  Reach out to the Graduate Medical Education office for information about benefits, contracts, orientation or graduation.
Departments

— College of Medicine — Department of Biochemistry and Molecular Biology — Our Faculty — Prakash Kshirsagar, PhD

Prakash Kshirsagar, PhD

Assistant Professor, UNMC Department of Biochemistry and Molecular Biology

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Phone: 402-559-7754

Prakash Kshirsagar, PhD

The primary focus of our research is the development of advanced diagnostic technologies, recombinant protein-based nanoparticle vaccines (Nanovaccine), and therapeutic nanomedicines specifically designed to combat various types of cancers. We have been researching on designing advanced Nanobiosensing technologies to diagnose prostate and pancreatic cancers. These studies comprise developing advanced DNA-gold nanoparticle bioconjugates (i.e., DNA-AuNPs) for the direct (PCR-free), absolute, and highly sensitive quantification of serum-derived biomarkers, i.e., miRNAs, LncRNA, and MUC4 splice variants.

One of the main focuses of our research revolves around the formulation of novel recombinant MUC4 and MUC16 proteins-based Nano-liposomal vaccines and investigating their immunotherapeutic potential in treating pancreatic cancer. An additional crucial focus of our research involves the generation of mucin-based monoclonal antibodies and formulating therapeutic antibody-drug conjugates (ADCs) targeting MUC4 mucins and evaluating their efficacy against pancreatic cancer (PC) using preclinical mice models.

Another important aspect of our research is the synthesis and characterization of novel liposomal nanoparticles as an efficient microRNA (RNA) delivery system for advancing gene therapy in treating breast and lung cancer-associated brain metastasis. Another crucial segment of our research projects focuses on developing innovative peptide-conjugated, light-sensitive (Near-Infrared) gold nanomaterials for photothermal therapy for treating pediatric glioblastoma (pGBM).

Education

Bachelor's in Chemistry, University of Pune, Pune, India.
Master's in Organic ChemistryUniversity of Pune, Pune, India.
PhD, Biomolecular Nanotechnologies, Italian Institute of Technology, Italy.

Research

Development of advanced diagnostic technologies, recombinant protein-based nanoparticle vaccines (Nanovaccine), and therapeutic nanomedicines specifically designed to combat various types of cancers.