— College of Medicine — Department of Anesthesiology — About Us — Faculty — Faculty Bios — Kamalika Mukherjee, PhD

Kamalika Mukherjee, MSc, PhD

Assistant Professor, UNMC Department of Anesthesiology
Research Faculty

Research Interests

Identifying the key proteins and RNAs present in the extracellular vehicles (EVs) derived from natural sources and glial cells that have immunomodulatory role to affect the immunoinflammatory processes in degenerating brain.
Using proteomic and transcriptomics analyses of EVs isolated from natural sources, to explore the anti-inflammatory potential of EVs and their cargo proteins and RNA to restrict the inflammatory processes in Alzheimer’s Disease and Parkinson’s Disease mouse brain.
Exploring the RNA binding proteins identified by proteomic approaches to use them to target and load specific RNA e., gRNA or siRNA to deliver to target tissues to remove the residual HIV infection from the brain of humanized mouse model of HIV, using extracellular vesicles isolated from natural sources as a potential loading vehicle.

Publications

Hom Choudhury, S., Bhattacharjee, S., Mukherjee, K*., Bhattacharyya, S.N*. (2024)
Human antigen R transfers miRNA to Syntaxin 5 to synergize miRNA export from activated macrophages. J Biol Chem. 300(4):107170. doi: 10.1016/j.jbc.2024.107170. Epub 2024 Mar 15.PMID: 38492777 (*Co-corresponding authors)
Ghosh, S., Hom Choudhury, S., Mukherjee, K*., Bhattacharyya, S.N*. (2024) HuR-miRNA complex activates RAS GTPase RalA to facilitate endosome targeting and extracellular export of miRNAs. J Biol Chem. 300(3):105750. doi: 10.1016/j.jbc.2024.105750. Epub 2024 Feb 14. PMID: 38360271 (*Co-corresponding authors)
Bandyopadhyay, D., Basu, S., Mukherjee, I., Chakrabarti, S., Chakrabarti, P., Mukherjee, K., Bhattacharyya, N. (2023) Accelerated export of Dicer1 from lipid-challenged hepatocytes buffers cellular miRNA-122 levels and prevents cell death.. J Biol Chem. 299(8):104999. doi: 10.1016/j.jbc.2023.104999. Epub 2023 Jun 30. PMID: 37394005
Ganguly S, Ghoshal B, Banerji I, Bhattacharjee S, Chakraborty S, Goswami A, Mukherjee K*, Bhattacharyya SN*. Leishmania survives by exporting miR-146a from infected to resident cells to subjugate inflammation. Life Sci Alliance. 2022 Jun;5(6). doi: 10.26508/lsa.202101229. Print 2022 Jun. PubMed PMID: 35210329; PubMed Central PMCID: PMC8881743. (*Co-corresponding authors)

Funding